Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders

Members of the Shank protein family are master scaffolds of the postsynaptic architecture and mutations within the SHANK genes are causally associated with autism spectrum disorders (ASDs). We generated a Shank2-Shank3 double knockout mouse that is showing severe autism related core symptoms, as wel...

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Detalles Bibliográficos
Autores principales: Garrido, Débora, Beretta, Stefania, Grabrucker, Stefanie, Bauer, Helen Friedericke, Bayer, David, Sala, Carlo, Verpelli, Chiara, Roselli, Francesco, Bockmann, Juergen, Proepper, Christian, Catanese, Alberto, Boeckers, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763120/
https://www.ncbi.nlm.nih.gov/pubmed/36100669
http://dx.doi.org/10.1038/s41380-022-01756-8

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