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Shift work with and without night shifts and breast cancer risk in a cohort study from Finland
OBJECTIVES: To examine the association of shift work with and without night work with breast cancer among women in the public sector. METHODS: Using the Finnish Public Sector cohort study (N=33 359, mean age of 40.6 years at baseline), we investigated the associations of shift work and potential con...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763178/ https://www.ncbi.nlm.nih.gov/pubmed/35948413 http://dx.doi.org/10.1136/oemed-2022-108347 |
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author | Härmä, Mikko Ojajärvi, Anneli Koskinen, Aki Lie, Jenny-Anne Hansen, Johnni |
author_facet | Härmä, Mikko Ojajärvi, Anneli Koskinen, Aki Lie, Jenny-Anne Hansen, Johnni |
author_sort | Härmä, Mikko |
collection | PubMed |
description | OBJECTIVES: To examine the association of shift work with and without night work with breast cancer among women in the public sector. METHODS: Using the Finnish Public Sector cohort study (N=33 359, mean age of 40.6 years at baseline), we investigated the associations of shift work and potential confounders with incident breast cancer. Exposure to permanent day work or shift work was defined from first two consecutive surveys from 2000, 2004, 2008 or 2012 and past information on exposure in a subcohort (n=20 786). Incident cases of breast cancer (n=1129) were retrieved from the National Cancer Register and the cohort members were followed to the end of 2016. HR and 95% CI from Cox proportional hazard regression models were calculated. RESULTS: Shift work with and without night shifts was not overall associated with breast cancer. When stratified according to age, both shift work without nights (HR 2.01, 95% CI 1.12 to 3.60) and shift work with nights (OR 2.05, 95% CI 1.04 to 4.01) were associated with an increased risk after a period of 10 years or more follow-up among women aged 50 years or older, when adjusted for age, socioeconomic status, children, smoking, alcohol and body mass index. In a subgroup with past information on exposure to shift work, the increased risk by longer exposure to shift work was not significant. CONCLUSIONS: This study provides support for an increased risk of breast cancer among elderly shift workers. However, insufficient information on exposure and intensity of night work may attenuate the risk estimates. |
format | Online Article Text |
id | pubmed-9763178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-97631782022-12-21 Shift work with and without night shifts and breast cancer risk in a cohort study from Finland Härmä, Mikko Ojajärvi, Anneli Koskinen, Aki Lie, Jenny-Anne Hansen, Johnni Occup Environ Med Workplace OBJECTIVES: To examine the association of shift work with and without night work with breast cancer among women in the public sector. METHODS: Using the Finnish Public Sector cohort study (N=33 359, mean age of 40.6 years at baseline), we investigated the associations of shift work and potential confounders with incident breast cancer. Exposure to permanent day work or shift work was defined from first two consecutive surveys from 2000, 2004, 2008 or 2012 and past information on exposure in a subcohort (n=20 786). Incident cases of breast cancer (n=1129) were retrieved from the National Cancer Register and the cohort members were followed to the end of 2016. HR and 95% CI from Cox proportional hazard regression models were calculated. RESULTS: Shift work with and without night shifts was not overall associated with breast cancer. When stratified according to age, both shift work without nights (HR 2.01, 95% CI 1.12 to 3.60) and shift work with nights (OR 2.05, 95% CI 1.04 to 4.01) were associated with an increased risk after a period of 10 years or more follow-up among women aged 50 years or older, when adjusted for age, socioeconomic status, children, smoking, alcohol and body mass index. In a subgroup with past information on exposure to shift work, the increased risk by longer exposure to shift work was not significant. CONCLUSIONS: This study provides support for an increased risk of breast cancer among elderly shift workers. However, insufficient information on exposure and intensity of night work may attenuate the risk estimates. BMJ Publishing Group 2023-01 2022-08-10 /pmc/articles/PMC9763178/ /pubmed/35948413 http://dx.doi.org/10.1136/oemed-2022-108347 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Workplace Härmä, Mikko Ojajärvi, Anneli Koskinen, Aki Lie, Jenny-Anne Hansen, Johnni Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title | Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title_full | Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title_fullStr | Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title_full_unstemmed | Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title_short | Shift work with and without night shifts and breast cancer risk in a cohort study from Finland |
title_sort | shift work with and without night shifts and breast cancer risk in a cohort study from finland |
topic | Workplace |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763178/ https://www.ncbi.nlm.nih.gov/pubmed/35948413 http://dx.doi.org/10.1136/oemed-2022-108347 |
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