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Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study

INTRODUCTION: Children requiring multiple blood transfusions are at high risk of transfusion-transmissible infections (TTIs). Lao People’s Democratic Republic is a low-resource setting where donor blood screening faces challenges. This study aimed to determine the burden of TTIs in children in Vient...

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Autores principales: Khounvisith, Vilaysone, Saysouligno, Sonephet, Souvanlasy, Bounpalisone, Billamay, Somxay, Mongkhoune, Sodaly, Vongphachanh, Bounta, Snoeck, Chantal J, Black, Antony P, Muller, Claude P, Hübschen, Judith M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763200/
https://www.ncbi.nlm.nih.gov/pubmed/36344216
http://dx.doi.org/10.1136/archdischild-2022-324629
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author Khounvisith, Vilaysone
Saysouligno, Sonephet
Souvanlasy, Bounpalisone
Billamay, Somxay
Mongkhoune, Sodaly
Vongphachanh, Bounta
Snoeck, Chantal J
Black, Antony P
Muller, Claude P
Hübschen, Judith M
author_facet Khounvisith, Vilaysone
Saysouligno, Sonephet
Souvanlasy, Bounpalisone
Billamay, Somxay
Mongkhoune, Sodaly
Vongphachanh, Bounta
Snoeck, Chantal J
Black, Antony P
Muller, Claude P
Hübschen, Judith M
author_sort Khounvisith, Vilaysone
collection PubMed
description INTRODUCTION: Children requiring multiple blood transfusions are at high risk of transfusion-transmissible infections (TTIs). Lao People’s Democratic Republic is a low-resource setting where donor blood screening faces challenges. This study aimed to determine the burden of TTIs in children in Vientiane Capital. METHODS: 300 children with transfusion history and 300 controls were recruited. In addition, 49 newly diagnosed transfusion recipients were followed for up to 12 months. Serum was tested for hepatitis B surface antigen and IgG antibodies against parvovirus B19, hepatitis B, C and E viruses. RESULTS: The patients had a similar prevalence of anti-hepatitis B core antibodies (56; 18.7%) and hepatitis B surface antigen (8; 2.7%) as the controls (58; 19.3% and 9; 3.0%, respectively). However, there was a higher prevalence of an antibody profile suggestive of hepatitis B vaccination (anti-hepatitis B surface antibody positive/anti-hepatitis B core antibody negative) in the transfused group (140/299; 46.8%) than in controls (77/300; 25.7%, p<0.01). All other markers were similar in the patients and controls or higher in the controls: anti-hepatitis C virus (2.7% and 3.3%, p=0.6), anti-hepatitis E virus (7.5% and 12.7%, p=0.006) and anti-parvovirus B19 (2.4% and 8.5%, p=0.001). The longitudinal cohort did not show an increase in any marker over time. CONCLUSION: Our results suggest no significant role of TTIs in Lao children. The higher prevalence of the hepatitis B vaccination profile in transfusion recipients showed that recommendations to vaccinate before commencing transfusions is at least partially implemented, although there is room for improvement.
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spelling pubmed-97632002022-12-21 Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study Khounvisith, Vilaysone Saysouligno, Sonephet Souvanlasy, Bounpalisone Billamay, Somxay Mongkhoune, Sodaly Vongphachanh, Bounta Snoeck, Chantal J Black, Antony P Muller, Claude P Hübschen, Judith M Arch Dis Child Global Child Health INTRODUCTION: Children requiring multiple blood transfusions are at high risk of transfusion-transmissible infections (TTIs). Lao People’s Democratic Republic is a low-resource setting where donor blood screening faces challenges. This study aimed to determine the burden of TTIs in children in Vientiane Capital. METHODS: 300 children with transfusion history and 300 controls were recruited. In addition, 49 newly diagnosed transfusion recipients were followed for up to 12 months. Serum was tested for hepatitis B surface antigen and IgG antibodies against parvovirus B19, hepatitis B, C and E viruses. RESULTS: The patients had a similar prevalence of anti-hepatitis B core antibodies (56; 18.7%) and hepatitis B surface antigen (8; 2.7%) as the controls (58; 19.3% and 9; 3.0%, respectively). However, there was a higher prevalence of an antibody profile suggestive of hepatitis B vaccination (anti-hepatitis B surface antibody positive/anti-hepatitis B core antibody negative) in the transfused group (140/299; 46.8%) than in controls (77/300; 25.7%, p<0.01). All other markers were similar in the patients and controls or higher in the controls: anti-hepatitis C virus (2.7% and 3.3%, p=0.6), anti-hepatitis E virus (7.5% and 12.7%, p=0.006) and anti-parvovirus B19 (2.4% and 8.5%, p=0.001). The longitudinal cohort did not show an increase in any marker over time. CONCLUSION: Our results suggest no significant role of TTIs in Lao children. The higher prevalence of the hepatitis B vaccination profile in transfusion recipients showed that recommendations to vaccinate before commencing transfusions is at least partially implemented, although there is room for improvement. BMJ Publishing Group 2023-01 2022-11-07 /pmc/articles/PMC9763200/ /pubmed/36344216 http://dx.doi.org/10.1136/archdischild-2022-324629 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Global Child Health
Khounvisith, Vilaysone
Saysouligno, Sonephet
Souvanlasy, Bounpalisone
Billamay, Somxay
Mongkhoune, Sodaly
Vongphachanh, Bounta
Snoeck, Chantal J
Black, Antony P
Muller, Claude P
Hübschen, Judith M
Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title_full Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title_fullStr Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title_full_unstemmed Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title_short Hepatitis B virus and other transfusion-transmissible infections in child blood recipients in Lao People’s Democratic Republic: a hospital-based study
title_sort hepatitis b virus and other transfusion-transmissible infections in child blood recipients in lao people’s democratic republic: a hospital-based study
topic Global Child Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763200/
https://www.ncbi.nlm.nih.gov/pubmed/36344216
http://dx.doi.org/10.1136/archdischild-2022-324629
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