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Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study
OBJECTIVES: Peru has had the highest death toll from the pandemic worldwide; however, it is not clear what the effects of the different variants on these outcomes are. The study aimed to evaluate the risk of death, hospitalization, and intensive care unit (ICU) admission rates of COVID-19 according...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763211/ https://www.ncbi.nlm.nih.gov/pubmed/36563957 http://dx.doi.org/10.1016/j.ijid.2022.12.020 |
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author | Fano-Sizgorich, Diego Vásquez-Velásquez, Cinthya Orellana, Laura R. Ponce-Torres, Christian Gamboa-Serpa, Henry Alvarez-Huambachano, Keyla Gonzales, Gustavo F. |
author_facet | Fano-Sizgorich, Diego Vásquez-Velásquez, Cinthya Orellana, Laura R. Ponce-Torres, Christian Gamboa-Serpa, Henry Alvarez-Huambachano, Keyla Gonzales, Gustavo F. |
author_sort | Fano-Sizgorich, Diego |
collection | PubMed |
description | OBJECTIVES: Peru has had the highest death toll from the pandemic worldwide; however, it is not clear what the effects of the different variants on these outcomes are. The study aimed to evaluate the risk of death, hospitalization, and intensive care unit (ICU) admission rates of COVID-19 according to the SARS-CoV-2 variants detected in Peru from March 2020-February 2022. METHODS: Retrospective study using open-access databases were published by the Peruvian Ministry of Health. Databases of genomic sequencing, death, COVID-19 cases, hospitalization and ICU, and vaccination were used. Crude and adjusted Cox proportional hazards regressions with clustered variances were modeled to calculate the hazard ratio (HR) of outcomes by variant. RESULTS: Lambda variant had the highest risk of death (HR 1.92, 95% CI 1.37-2.68), whereas the Delta variant had the lowest risk (HR 0.50, 95% CI 0.31-0.82). Mu variant had the highest risk of hospitalization (HR: 2.39, 95% CI 1.56-3.67), Omicron the lowest (HR 0.45, 95%CI 0.23-0.90), and Gamma had the highest ICU admission rate (HR 1.95, 95%CI 1.40-2.71). CONCLUSION: SARS-CoV-2 variants showed distinctive risks of clinical outcomes, which could have implications for the management of infected persons during the pandemic. |
format | Online Article Text |
id | pubmed-9763211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97632112022-12-20 Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study Fano-Sizgorich, Diego Vásquez-Velásquez, Cinthya Orellana, Laura R. Ponce-Torres, Christian Gamboa-Serpa, Henry Alvarez-Huambachano, Keyla Gonzales, Gustavo F. Int J Infect Dis Article OBJECTIVES: Peru has had the highest death toll from the pandemic worldwide; however, it is not clear what the effects of the different variants on these outcomes are. The study aimed to evaluate the risk of death, hospitalization, and intensive care unit (ICU) admission rates of COVID-19 according to the SARS-CoV-2 variants detected in Peru from March 2020-February 2022. METHODS: Retrospective study using open-access databases were published by the Peruvian Ministry of Health. Databases of genomic sequencing, death, COVID-19 cases, hospitalization and ICU, and vaccination were used. Crude and adjusted Cox proportional hazards regressions with clustered variances were modeled to calculate the hazard ratio (HR) of outcomes by variant. RESULTS: Lambda variant had the highest risk of death (HR 1.92, 95% CI 1.37-2.68), whereas the Delta variant had the lowest risk (HR 0.50, 95% CI 0.31-0.82). Mu variant had the highest risk of hospitalization (HR: 2.39, 95% CI 1.56-3.67), Omicron the lowest (HR 0.45, 95%CI 0.23-0.90), and Gamma had the highest ICU admission rate (HR 1.95, 95%CI 1.40-2.71). CONCLUSION: SARS-CoV-2 variants showed distinctive risks of clinical outcomes, which could have implications for the management of infected persons during the pandemic. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023-02 2022-12-20 /pmc/articles/PMC9763211/ /pubmed/36563957 http://dx.doi.org/10.1016/j.ijid.2022.12.020 Text en © 2022 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Fano-Sizgorich, Diego Vásquez-Velásquez, Cinthya Orellana, Laura R. Ponce-Torres, Christian Gamboa-Serpa, Henry Alvarez-Huambachano, Keyla Gonzales, Gustavo F. Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title | Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title_full | Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title_fullStr | Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title_full_unstemmed | Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title_short | Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study |
title_sort | risk of death, hospitalization and intensive care unit admission by sars-cov-2 variants in peru: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763211/ https://www.ncbi.nlm.nih.gov/pubmed/36563957 http://dx.doi.org/10.1016/j.ijid.2022.12.020 |
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