Sustained activation of EGFR-ERK1/2 signaling limits the response to tigecycline-induced mitochondrial respiratory deficiency in liver cancer

BACKGROUND: Identification of tumor dependencies is important for developing therapeutic strategies for liver cancer. METHODS: A genome-wide CRISPR screen was performed for finding critical vulnerabilities in liver cancer cells. Compounds screen, RNA sequencing, and human phospho-receptor tyrosine k...

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Detalles Bibliográficos
Autores principales: Zhou, Yangyang, Wang, Siying, Wu, Wei, Ling, Jing, Li, Haoyu, Jia, Qi, Zheng, Jiaojiao, Zheng, Xingling, Yu, Ruobing, Wu, Qiangxin, Shi, Yaoping, Lieftink, Cor, Beijersbergen, Roderick L., Yuan, Shengxian, Bernards, René, Jin, Haojie, Qin, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763382/
https://www.ncbi.nlm.nih.gov/pubmed/36502574
http://dx.doi.org/10.1016/j.ebiom.2022.104397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763382/
https://www.ncbi.nlm.nih.gov/pubmed/36502574
http://dx.doi.org/10.1016/j.ebiom.2022.104397

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