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Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow
Among the different polymers (proteins, polysaccharides, etc.) that make up natural fibers, fibroin is a protein produced by silk spinning animals, which have developed an optimized system for the conversion of a highly concentrated solution of this protein into high-performance solid fibers. This p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763433/ https://www.ncbi.nlm.nih.gov/pubmed/36536025 http://dx.doi.org/10.1038/s41598-022-26137-7 |
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author | Gañán-Calvo, Alfonso M. Blanco-Trejo, Sergio Ruiz-López, Miguel Guinea, Gustavo V. Modesto-López, Luis B. Pérez-Rigueiro, José |
author_facet | Gañán-Calvo, Alfonso M. Blanco-Trejo, Sergio Ruiz-López, Miguel Guinea, Gustavo V. Modesto-López, Luis B. Pérez-Rigueiro, José |
author_sort | Gañán-Calvo, Alfonso M. |
collection | PubMed |
description | Among the different polymers (proteins, polysaccharides, etc.) that make up natural fibers, fibroin is a protein produced by silk spinning animals, which have developed an optimized system for the conversion of a highly concentrated solution of this protein into high-performance solid fibers. This protein undergoes a self-assembly process in the silk glands that result from chemical gradients and by the application of mechanical stresses during the last step of the process. In the quest for a process that could mimic natural spinning at massive scales, we have discovered that turbulence offers a novel and promising solution: a turbulent liquid jet can be formed by a chemically green and simple coagulating liquid (a diluted solution of acetic acid in etanol) co-flowing with a concentrated solution of fibroin in water by the use of a Flow Blurring nebulizer. In this system, (a) the co-flowing coagulant liquid extracts water from the original protein solution and, simultaneously, (b) the self-assembled proteins are subjected to mechanical actions, including splitting and stretching. Given the non-negligible produced content with the size and appearance of natural silk, the stochastic distribution of those effects in our process should contain the range of natural ones found in animals. The resulting easily functionalizable and tunable one-step material is 100% biocompatible, and our method a perfect candidate to large-scale, low-cost, green and sustainable processing of fibroin for fibres and textiles. |
format | Online Article Text |
id | pubmed-9763433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-97634332022-12-21 Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow Gañán-Calvo, Alfonso M. Blanco-Trejo, Sergio Ruiz-López, Miguel Guinea, Gustavo V. Modesto-López, Luis B. Pérez-Rigueiro, José Sci Rep Article Among the different polymers (proteins, polysaccharides, etc.) that make up natural fibers, fibroin is a protein produced by silk spinning animals, which have developed an optimized system for the conversion of a highly concentrated solution of this protein into high-performance solid fibers. This protein undergoes a self-assembly process in the silk glands that result from chemical gradients and by the application of mechanical stresses during the last step of the process. In the quest for a process that could mimic natural spinning at massive scales, we have discovered that turbulence offers a novel and promising solution: a turbulent liquid jet can be formed by a chemically green and simple coagulating liquid (a diluted solution of acetic acid in etanol) co-flowing with a concentrated solution of fibroin in water by the use of a Flow Blurring nebulizer. In this system, (a) the co-flowing coagulant liquid extracts water from the original protein solution and, simultaneously, (b) the self-assembled proteins are subjected to mechanical actions, including splitting and stretching. Given the non-negligible produced content with the size and appearance of natural silk, the stochastic distribution of those effects in our process should contain the range of natural ones found in animals. The resulting easily functionalizable and tunable one-step material is 100% biocompatible, and our method a perfect candidate to large-scale, low-cost, green and sustainable processing of fibroin for fibres and textiles. Nature Publishing Group UK 2022-12-19 /pmc/articles/PMC9763433/ /pubmed/36536025 http://dx.doi.org/10.1038/s41598-022-26137-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Gañán-Calvo, Alfonso M. Blanco-Trejo, Sergio Ruiz-López, Miguel Guinea, Gustavo V. Modesto-López, Luis B. Pérez-Rigueiro, José Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title | Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title_full | Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title_fullStr | Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title_full_unstemmed | Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title_short | Massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
title_sort | massive production of fibroin nano-fibrous biomaterial by turbulent co-flow |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763433/ https://www.ncbi.nlm.nih.gov/pubmed/36536025 http://dx.doi.org/10.1038/s41598-022-26137-7 |
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