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Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective
Multiple myeloma (MM) is a prevalent hematological malignancy. Resource-constrained settings such as the Middle East are particularly burdened by the increasing trends in MM morbidity and mortality in addition to challenges in the management of MM. It thus becomes necessary to identify and address d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763519/ https://www.ncbi.nlm.nih.gov/pubmed/36040650 http://dx.doi.org/10.1007/s44228-022-00017-3 |
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author | Ibrahim, Ahmad Chamseddine, Nabil El-cheikh, Jean Hanna, Colette Moukadem, Walid Nasr, Fady Younis, Ahmad Bazarbachi, Ali |
author_facet | Ibrahim, Ahmad Chamseddine, Nabil El-cheikh, Jean Hanna, Colette Moukadem, Walid Nasr, Fady Younis, Ahmad Bazarbachi, Ali |
author_sort | Ibrahim, Ahmad |
collection | PubMed |
description | Multiple myeloma (MM) is a prevalent hematological malignancy. Resource-constrained settings such as the Middle East are particularly burdened by the increasing trends in MM morbidity and mortality in addition to challenges in the management of MM. It thus becomes necessary to identify and address debatable areas of current practice and gaps in the management of MM in the Middle East. With a special focus on the Lebanese situation, the first-line treatment of the very elderly (> 80 years old) is discussed, in addition to the impact of relapse type (biochemical or clinical relapse) on maintenance therapy, the choice of first relapse therapy in relation to maintenance therapy, and the role of MRD in the MM treatment landscape. The need for realistic management guidelines accounting for local resources and expertise, in addition to the reflection of drug accessibility and cost on clinical practice are recognized. |
format | Online Article Text |
id | pubmed-9763519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-97635192023-01-04 Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective Ibrahim, Ahmad Chamseddine, Nabil El-cheikh, Jean Hanna, Colette Moukadem, Walid Nasr, Fady Younis, Ahmad Bazarbachi, Ali Clin Hematol Int Prespective Multiple myeloma (MM) is a prevalent hematological malignancy. Resource-constrained settings such as the Middle East are particularly burdened by the increasing trends in MM morbidity and mortality in addition to challenges in the management of MM. It thus becomes necessary to identify and address debatable areas of current practice and gaps in the management of MM in the Middle East. With a special focus on the Lebanese situation, the first-line treatment of the very elderly (> 80 years old) is discussed, in addition to the impact of relapse type (biochemical or clinical relapse) on maintenance therapy, the choice of first relapse therapy in relation to maintenance therapy, and the role of MRD in the MM treatment landscape. The need for realistic management guidelines accounting for local resources and expertise, in addition to the reflection of drug accessibility and cost on clinical practice are recognized. Springer Netherlands 2022-08-30 /pmc/articles/PMC9763519/ /pubmed/36040650 http://dx.doi.org/10.1007/s44228-022-00017-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Prespective Ibrahim, Ahmad Chamseddine, Nabil El-cheikh, Jean Hanna, Colette Moukadem, Walid Nasr, Fady Younis, Ahmad Bazarbachi, Ali Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title | Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title_full | Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title_fullStr | Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title_full_unstemmed | Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title_short | Management of Multiple Myeloma in the Middle East: Unmet Needs, Challenges and Perspective |
title_sort | management of multiple myeloma in the middle east: unmet needs, challenges and perspective |
topic | Prespective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763519/ https://www.ncbi.nlm.nih.gov/pubmed/36040650 http://dx.doi.org/10.1007/s44228-022-00017-3 |
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