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Solvent modulation in peptide sub-microfibers obtained by solution blow spinning

Peptides possess high chemical diversity at the amino acid sequence level, which further translates into versatile functions. Peptides with self-assembling properties can be processed into diverse formats giving rise to bio-based materials. Peptide-based spun fibers are an interesting format due to...

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Autores principales: Dias, Ana Margarida Gonçalves Carvalho, Cena, Cícero, Lutz-Bueno, Viviane, Mezzenga, Raffaele, Marques, Ana, Ferreira, Isabel, Roque, Ana Cecília Afonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763608/
https://www.ncbi.nlm.nih.gov/pubmed/36561144
http://dx.doi.org/10.3389/fchem.2022.1054347
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author Dias, Ana Margarida Gonçalves Carvalho
Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
author_facet Dias, Ana Margarida Gonçalves Carvalho
Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
author_sort Dias, Ana Margarida Gonçalves Carvalho
collection PubMed
description Peptides possess high chemical diversity at the amino acid sequence level, which further translates into versatile functions. Peptides with self-assembling properties can be processed into diverse formats giving rise to bio-based materials. Peptide-based spun fibers are an interesting format due to high surface-area and versatility, though the field is still in its infancy due to the challenges in applying the synthetic polymer spinning processes to protein fibers to peptides. In this work we show the use of solution blow-spinning to produce peptide fibers. Peptide fiber formation was assisted by the polymer poly (vinyl pyrrolidone) (PVP) in two solvent conditions. Peptide miscibility and further self-assembling propensity in the solvents played a major role in fiber formation. When employing acetic acid as solvent, peptide fibers (0.5 μm) are formed around PVP fibers (0.75 μm), whereas in isopropanol only one type of fibers are formed, consisting of mixed peptide and PVP (1 μm). This report highlights solvent modulation as a mean to obtain different peptide sub-microfibers via a single injection nozzle in solution blow spinning. We anticipate this strategy to be applied to other small peptides with self-assembly propensity to obtain multi-functional proteinaceous fibers.
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spelling pubmed-97636082022-12-21 Solvent modulation in peptide sub-microfibers obtained by solution blow spinning Dias, Ana Margarida Gonçalves Carvalho Cena, Cícero Lutz-Bueno, Viviane Mezzenga, Raffaele Marques, Ana Ferreira, Isabel Roque, Ana Cecília Afonso Front Chem Chemistry Peptides possess high chemical diversity at the amino acid sequence level, which further translates into versatile functions. Peptides with self-assembling properties can be processed into diverse formats giving rise to bio-based materials. Peptide-based spun fibers are an interesting format due to high surface-area and versatility, though the field is still in its infancy due to the challenges in applying the synthetic polymer spinning processes to protein fibers to peptides. In this work we show the use of solution blow-spinning to produce peptide fibers. Peptide fiber formation was assisted by the polymer poly (vinyl pyrrolidone) (PVP) in two solvent conditions. Peptide miscibility and further self-assembling propensity in the solvents played a major role in fiber formation. When employing acetic acid as solvent, peptide fibers (0.5 μm) are formed around PVP fibers (0.75 μm), whereas in isopropanol only one type of fibers are formed, consisting of mixed peptide and PVP (1 μm). This report highlights solvent modulation as a mean to obtain different peptide sub-microfibers via a single injection nozzle in solution blow spinning. We anticipate this strategy to be applied to other small peptides with self-assembly propensity to obtain multi-functional proteinaceous fibers. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9763608/ /pubmed/36561144 http://dx.doi.org/10.3389/fchem.2022.1054347 Text en Copyright © 2022 Dias, Cena, Lutz-Bueno, Mezzenga, Marques, Ferreira and Roque. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Dias, Ana Margarida Gonçalves Carvalho
Cena, Cícero
Lutz-Bueno, Viviane
Mezzenga, Raffaele
Marques, Ana
Ferreira, Isabel
Roque, Ana Cecília Afonso
Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_full Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_fullStr Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_full_unstemmed Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_short Solvent modulation in peptide sub-microfibers obtained by solution blow spinning
title_sort solvent modulation in peptide sub-microfibers obtained by solution blow spinning
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763608/
https://www.ncbi.nlm.nih.gov/pubmed/36561144
http://dx.doi.org/10.3389/fchem.2022.1054347
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