The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets

N6-methyladenosinen (m(6)A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m(6)A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent re...

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Detalles Bibliográficos
Autores principales: Li, Gaofeng, Fu, Qiru, Liu, Cong, Peng, Yuxi, Gong, Jun, Li, Shilan, Huang, Yan, Zhang, Haiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763625/
https://www.ncbi.nlm.nih.gov/pubmed/36561529
http://dx.doi.org/10.3389/fonc.2022.1074307
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author Li, Gaofeng
Fu, Qiru
Liu, Cong
Peng, Yuxi
Gong, Jun
Li, Shilan
Huang, Yan
Zhang, Haiyuan
author_facet Li, Gaofeng
Fu, Qiru
Liu, Cong
Peng, Yuxi
Gong, Jun
Li, Shilan
Huang, Yan
Zhang, Haiyuan
author_sort Li, Gaofeng
collection PubMed
description N6-methyladenosinen (m(6)A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m(6)A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked m(6)A RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of m(6)A RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of m(6)A RNA modification in GC.
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spelling pubmed-97636252022-12-21 The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets Li, Gaofeng Fu, Qiru Liu, Cong Peng, Yuxi Gong, Jun Li, Shilan Huang, Yan Zhang, Haiyuan Front Oncol Oncology N6-methyladenosinen (m(6)A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m(6)A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked m(6)A RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of m(6)A RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of m(6)A RNA modification in GC. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9763625/ /pubmed/36561529 http://dx.doi.org/10.3389/fonc.2022.1074307 Text en Copyright © 2022 Li, Fu, Liu, Peng, Gong, Li, Huang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Gaofeng
Fu, Qiru
Liu, Cong
Peng, Yuxi
Gong, Jun
Li, Shilan
Huang, Yan
Zhang, Haiyuan
The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title_full The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title_fullStr The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title_full_unstemmed The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title_short The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
title_sort regulatory role of n6-methyladenosine rna modification in gastric cancer: molecular mechanisms and potential therapeutic targets
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763625/
https://www.ncbi.nlm.nih.gov/pubmed/36561529
http://dx.doi.org/10.3389/fonc.2022.1074307
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