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Two squamous cell carcinomas of the skin in a patient with Lynch syndrome

INTRODUCTION AND IMPORTANCE: Although synchronous and metachronous tumours of the bowel are well known associations of Lynch syndrome, the association of skin malignancies in such patients are extremely rare. CASE PRESENTATION: A 40-year-old Sri Lankan man with a strong family history of colorectal...

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Autores principales: Basnayake, Oshan, Jayarajah, Umesh, Subasinghe, Duminda, Rajapakse, Kavinda, Beneragama, Thushan, Sivaganesh, Sivasuriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763668/
https://www.ncbi.nlm.nih.gov/pubmed/36512881
http://dx.doi.org/10.1016/j.ijscr.2022.107822
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author Basnayake, Oshan
Jayarajah, Umesh
Subasinghe, Duminda
Rajapakse, Kavinda
Beneragama, Thushan
Sivaganesh, Sivasuriya
author_facet Basnayake, Oshan
Jayarajah, Umesh
Subasinghe, Duminda
Rajapakse, Kavinda
Beneragama, Thushan
Sivaganesh, Sivasuriya
author_sort Basnayake, Oshan
collection PubMed
description INTRODUCTION AND IMPORTANCE: Although synchronous and metachronous tumours of the bowel are well known associations of Lynch syndrome, the association of skin malignancies in such patients are extremely rare. CASE PRESENTATION: A 40-year-old Sri Lankan man with a strong family history of colorectal cancer had an extended right hemicolectomy for a moderately differentiated adenocarcinoma. Two months after surgery, he developed two discrete ulcerative skin lesions in the chin and occipital region which excision biopsy confirmed to be squamous cell carcinoma. After more than two years of follow-up, patient remains disease free. CLINICAL DISCUSSION: The Muir Torre variant of Lynch syndrome is characteristically associated with sebaceous adenomas and carcinomas, though occurence of squamous cell carcinomas are rare. In reported cases, defective mismatch repair genes associated with Lynch syndrome may suggest an increased predisposition for squamous cell carcinomas. CONCLUSION: Patients with Lynch syndrome should be educated on the importance of seeking an early medical consult for new skin lesions and raising awareness of this rare phenomenon for physicians involved in follow up is important.
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spelling pubmed-97636682022-12-21 Two squamous cell carcinomas of the skin in a patient with Lynch syndrome Basnayake, Oshan Jayarajah, Umesh Subasinghe, Duminda Rajapakse, Kavinda Beneragama, Thushan Sivaganesh, Sivasuriya Int J Surg Case Rep Case Report INTRODUCTION AND IMPORTANCE: Although synchronous and metachronous tumours of the bowel are well known associations of Lynch syndrome, the association of skin malignancies in such patients are extremely rare. CASE PRESENTATION: A 40-year-old Sri Lankan man with a strong family history of colorectal cancer had an extended right hemicolectomy for a moderately differentiated adenocarcinoma. Two months after surgery, he developed two discrete ulcerative skin lesions in the chin and occipital region which excision biopsy confirmed to be squamous cell carcinoma. After more than two years of follow-up, patient remains disease free. CLINICAL DISCUSSION: The Muir Torre variant of Lynch syndrome is characteristically associated with sebaceous adenomas and carcinomas, though occurence of squamous cell carcinomas are rare. In reported cases, defective mismatch repair genes associated with Lynch syndrome may suggest an increased predisposition for squamous cell carcinomas. CONCLUSION: Patients with Lynch syndrome should be educated on the importance of seeking an early medical consult for new skin lesions and raising awareness of this rare phenomenon for physicians involved in follow up is important. Elsevier 2022-12-01 /pmc/articles/PMC9763668/ /pubmed/36512881 http://dx.doi.org/10.1016/j.ijscr.2022.107822 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Basnayake, Oshan
Jayarajah, Umesh
Subasinghe, Duminda
Rajapakse, Kavinda
Beneragama, Thushan
Sivaganesh, Sivasuriya
Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title_full Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title_fullStr Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title_full_unstemmed Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title_short Two squamous cell carcinomas of the skin in a patient with Lynch syndrome
title_sort two squamous cell carcinomas of the skin in a patient with lynch syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763668/
https://www.ncbi.nlm.nih.gov/pubmed/36512881
http://dx.doi.org/10.1016/j.ijscr.2022.107822
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