Molecular properties and regulation of NAD(+) kinase (NADK)

Nicotinamide adenine dinucleotide (NAD(+)) kinase (NADK) phosphorylates NAD(+), thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria, plants and mammals. In mammals, NADK is acti...

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Detalles Bibliográficos
Autores principales: Oka, Shin-ichi, Titus, Allen Sam, Zablocki, Daniela, Sadoshima, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763689/
https://www.ncbi.nlm.nih.gov/pubmed/36512915
http://dx.doi.org/10.1016/j.redox.2022.102561
Descripción
Sumario:Nicotinamide adenine dinucleotide (NAD(+)) kinase (NADK) phosphorylates NAD(+), thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria, plants and mammals. In mammals, NADK is activated by phosphorylation and protein-protein interaction. Recent studies conducted using genetically altered models validate the essential role of NADK in cellular redox homeostasis and metabolism in multicellular organisms. Here, we describe the evolutionary conservation, molecular properties, and signaling mechanisms and discuss the pathophysiological significance of NADK.

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