The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages

The NLRP3 inflammasome is a critical component of innate immunity that defends the host from microbial infections. However, its aberrant activation contributes to the pathogenesis of several inflammatory diseases. Activation of the NLRP3 inflammasome induces the secretion of proinflammatory cytokine...

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Detalles Bibliográficos
Autores principales: Duan, Yanhui, Wang, Jihong, Cai, Juan, Kelley, Nathan, He, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763864/
https://www.ncbi.nlm.nih.gov/pubmed/36403854
http://dx.doi.org/10.1016/j.jbc.2022.102717

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