Cargando…
Role of the membrane anchor in the regulation of Lck activity
Theoretical work suggests that collective spatiotemporal behavior of integral membrane proteins should be modulated by boundary lipids sheathing their membrane anchors. Here, we show evidence for this prediction while investigating the mechanism for maintaining a steady amount of the active form of...
Autores principales: | Porciello, Nicla, Cipria, Deborah, Masi, Giulia, Lanz, Anna-Lisa, Milanetti, Edoardo, Grottesi, Alessandro, Howie, Duncan, Cobbold, Steve P., Schermelleh, Lothar, He, Hai-Tao, D’Abramo, Marco, Destainville, Nicolas, Acuto, Oreste, Nika, Konstantina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763865/ https://www.ncbi.nlm.nih.gov/pubmed/36372231 http://dx.doi.org/10.1016/j.jbc.2022.102663 |
Ejemplares similares
-
Molecular Dynamics Simulations Reveal Canonical Conformations in Different pMHC/TCR Interactions
por: Alba, Josephine, et al.
Publicado: (2020) -
Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction
por: Nika, Konstantina, et al.
Publicado: (2010) -
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
por: Lanz, Anna-Lisa, et al.
Publicado: (2021) -
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
por: Lanz, Anna-Lisa, et al.
Publicado: (2021) -
Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)
por: Prakaash, Dheeraj, et al.
Publicado: (2022)