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Cushing’s syndrome is associated with altered adipokine profile

INTRODUCTION: Adipokines are signaling molecules involved in the integration of metabolism. Changes in their concentrations were observed in obesity, metabolic syndrome, diabetes mellitus and cardiovascular diseases, as well as endocrine disorders. Cushing’s syndrome is associated with metabolic dys...

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Autores principales: Dadej, Daniela, Szczepanek-Parulska, Ewelina, Wrotkowska, Elżbieta, Ruchała, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763882/
https://www.ncbi.nlm.nih.gov/pubmed/36561568
http://dx.doi.org/10.3389/fendo.2022.1032329
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author Dadej, Daniela
Szczepanek-Parulska, Ewelina
Wrotkowska, Elżbieta
Ruchała, Marek
author_facet Dadej, Daniela
Szczepanek-Parulska, Ewelina
Wrotkowska, Elżbieta
Ruchała, Marek
author_sort Dadej, Daniela
collection PubMed
description INTRODUCTION: Adipokines are signaling molecules involved in the integration of metabolism. Changes in their concentrations were observed in obesity, metabolic syndrome, diabetes mellitus and cardiovascular diseases, as well as endocrine disorders. Cushing’s syndrome is associated with metabolic dysregulation, but the significance of adipokines in this entity and related complications is largely unknown. The aim of our study was to determine the concentrations of adipokines: fetuin A, fatty acid binding protein 4 (FABP4) and retinol binding protein 4 (RBP4) in Cushing’s syndrome and to assess their relation to established cardiovascular and diabetes risk markers. METHODS: We examined 21 subjects with Cushing’s syndrome and 24 healthy controls in a cross-sectional manner. Venous blood samples were analysed for adipokines, cortisol, adrenocorticotrophin, glucose, insulin, glycated haemoglobin (HbA1c), triglycerides, cholesterol fractions, thyrotropin and free thyroid hormones concentrations. Patients’ body mass index (BMI) was evaluated, homeostatic model assessment-insulin resistance and Systematic Coronary Risk Evaluation (SCORE) were calculated. RESULTS: We found that the concentration of fetuin A was lower, while FABP4 and RBP4 concentrations were higher in Cushing’s syndrome compared to controls [156.4 ± 60.0 µg/ml vs 260.7 ± 49.6 µg/ml; 79.8 (35.2-156.1) ng/ml vs 27.9 (17.1-36.7) ng/ml and 34 (30-37.7) mg/l vs 25.8 (23.6-27.7) mg/l, respectively]. Fetuin A correlated inversely, while FABP4 and RBP4 positively, with the concentrations of urinary free cortisol and adrenocorticotrophin. Fetuin A was positively related to LDL-cholesterol, and negatively to SCORE and HbA1c. FABP4 was associated positively with BMI, HbA1c and triglycerides, while RBP4 correlated positively with triglycerides and systolic blood pressure. CONCLUSIONS: Adipokines’ concentrations change in hypercortisolism. Further research is needed to ascertain whether adipokines are involved in the development of metabolic complications accompanying Cushing’s syndrome or secondarily reflect metabolic dysregulation.
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spelling pubmed-97638822022-12-21 Cushing’s syndrome is associated with altered adipokine profile Dadej, Daniela Szczepanek-Parulska, Ewelina Wrotkowska, Elżbieta Ruchała, Marek Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Adipokines are signaling molecules involved in the integration of metabolism. Changes in their concentrations were observed in obesity, metabolic syndrome, diabetes mellitus and cardiovascular diseases, as well as endocrine disorders. Cushing’s syndrome is associated with metabolic dysregulation, but the significance of adipokines in this entity and related complications is largely unknown. The aim of our study was to determine the concentrations of adipokines: fetuin A, fatty acid binding protein 4 (FABP4) and retinol binding protein 4 (RBP4) in Cushing’s syndrome and to assess their relation to established cardiovascular and diabetes risk markers. METHODS: We examined 21 subjects with Cushing’s syndrome and 24 healthy controls in a cross-sectional manner. Venous blood samples were analysed for adipokines, cortisol, adrenocorticotrophin, glucose, insulin, glycated haemoglobin (HbA1c), triglycerides, cholesterol fractions, thyrotropin and free thyroid hormones concentrations. Patients’ body mass index (BMI) was evaluated, homeostatic model assessment-insulin resistance and Systematic Coronary Risk Evaluation (SCORE) were calculated. RESULTS: We found that the concentration of fetuin A was lower, while FABP4 and RBP4 concentrations were higher in Cushing’s syndrome compared to controls [156.4 ± 60.0 µg/ml vs 260.7 ± 49.6 µg/ml; 79.8 (35.2-156.1) ng/ml vs 27.9 (17.1-36.7) ng/ml and 34 (30-37.7) mg/l vs 25.8 (23.6-27.7) mg/l, respectively]. Fetuin A correlated inversely, while FABP4 and RBP4 positively, with the concentrations of urinary free cortisol and adrenocorticotrophin. Fetuin A was positively related to LDL-cholesterol, and negatively to SCORE and HbA1c. FABP4 was associated positively with BMI, HbA1c and triglycerides, while RBP4 correlated positively with triglycerides and systolic blood pressure. CONCLUSIONS: Adipokines’ concentrations change in hypercortisolism. Further research is needed to ascertain whether adipokines are involved in the development of metabolic complications accompanying Cushing’s syndrome or secondarily reflect metabolic dysregulation. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9763882/ /pubmed/36561568 http://dx.doi.org/10.3389/fendo.2022.1032329 Text en Copyright © 2022 Dadej, Szczepanek-Parulska, Wrotkowska and Ruchała https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Dadej, Daniela
Szczepanek-Parulska, Ewelina
Wrotkowska, Elżbieta
Ruchała, Marek
Cushing’s syndrome is associated with altered adipokine profile
title Cushing’s syndrome is associated with altered adipokine profile
title_full Cushing’s syndrome is associated with altered adipokine profile
title_fullStr Cushing’s syndrome is associated with altered adipokine profile
title_full_unstemmed Cushing’s syndrome is associated with altered adipokine profile
title_short Cushing’s syndrome is associated with altered adipokine profile
title_sort cushing’s syndrome is associated with altered adipokine profile
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763882/
https://www.ncbi.nlm.nih.gov/pubmed/36561568
http://dx.doi.org/10.3389/fendo.2022.1032329
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