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Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification

Glioneuronal tumours (GNT) are uncommon neoplasms, characterised by glial and neuronal differentiation. In the 5th edition of the World Health Organization (WHO) Classification, they are grouped under the heading “Glioneuronal and neuronal tumours”, which comprises fourteen different tumours, among...

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Autores principales: Barresi, Valeria, Gianno, Francesca, Marucci, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore srl 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763980/
https://www.ncbi.nlm.nih.gov/pubmed/36534423
http://dx.doi.org/10.32074/1591-951X-819
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author Barresi, Valeria
Gianno, Francesca
Marucci, Gianluca
author_facet Barresi, Valeria
Gianno, Francesca
Marucci, Gianluca
author_sort Barresi, Valeria
collection PubMed
description Glioneuronal tumours (GNT) are uncommon neoplasms, characterised by glial and neuronal differentiation. In the 5th edition of the World Health Organization (WHO) Classification, they are grouped under the heading “Glioneuronal and neuronal tumours”, which comprises fourteen different tumours, among which the diffuse glioneuronal tumour with oligodendroglioma-like cells and nuclear clusters (DGONC), myxoyd glioneuronal tumour (MGT) and multinodular and vacuolating neuronal tumour (MNVNT) are new types. MGT and MNVNT are classified WHO grade 1 and may be recognised and diagnosed by peculiar clinical-pathological features. DGONC was not assigned a WHO grade and was only provisionally included among GNT, due to the possibility that it rather represents an embryonal tumour type or subtype. Although the histopathological characteristics may be useful for its identification, the specific methylation profile is an essential diagnostic criterion for DGONC.
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spelling pubmed-97639802023-01-03 Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification Barresi, Valeria Gianno, Francesca Marucci, Gianluca Pathologica Review Glioneuronal tumours (GNT) are uncommon neoplasms, characterised by glial and neuronal differentiation. In the 5th edition of the World Health Organization (WHO) Classification, they are grouped under the heading “Glioneuronal and neuronal tumours”, which comprises fourteen different tumours, among which the diffuse glioneuronal tumour with oligodendroglioma-like cells and nuclear clusters (DGONC), myxoyd glioneuronal tumour (MGT) and multinodular and vacuolating neuronal tumour (MNVNT) are new types. MGT and MNVNT are classified WHO grade 1 and may be recognised and diagnosed by peculiar clinical-pathological features. DGONC was not assigned a WHO grade and was only provisionally included among GNT, due to the possibility that it rather represents an embryonal tumour type or subtype. Although the histopathological characteristics may be useful for its identification, the specific methylation profile is an essential diagnostic criterion for DGONC. Pacini Editore srl 2022-12-01 /pmc/articles/PMC9763980/ /pubmed/36534423 http://dx.doi.org/10.32074/1591-951X-819 Text en © 2022 Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Review
Barresi, Valeria
Gianno, Francesca
Marucci, Gianluca
Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title_full Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title_fullStr Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title_full_unstemmed Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title_short Newly recognised Tumour Types in Glioneuronal tumours according to the 5th edition of the CNS WHO Classification
title_sort newly recognised tumour types in glioneuronal tumours according to the 5th edition of the cns who classification
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763980/
https://www.ncbi.nlm.nih.gov/pubmed/36534423
http://dx.doi.org/10.32074/1591-951X-819
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