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Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Fašmon Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, Puente, Secundino López, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Aquilina, Gabriele, Brantom, Paul, Dierick, Noël, Martelli, Giovanna, Svensson, Kettil, Anguita, Montserrat, Brozzi, Rosella, Galobart, Jaume, Casanova, Jordi Ortuño, Pettenati, Elisa, Tarrés‐Call, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764037/
https://www.ncbi.nlm.nih.gov/pubmed/36545575
http://dx.doi.org/10.2903/j.efsa.2022.7701
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Aquilina, Gabriele
Brantom, Paul
Dierick, Noël
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Casanova, Jordi Ortuño
Pettenati, Elisa
Tarrés‐Call, Jordi
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Aquilina, Gabriele
Brantom, Paul
Dierick, Noël
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Casanova, Jordi Ortuño
Pettenati, Elisa
Tarrés‐Call, Jordi
collection PubMed
description Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The additive VTR‐phytase consists of 6‐phytase and it is available in solid and liquid forms. VTR phytase (liquid/solid) was produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.370). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR phytase (liquid/solid) produced by Komagataella phaffii CGMCC 7.370 is safe for all Suidae and all avian species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid VTR phytase and powder VTR phytase are non‐irritant to skin or eyes but should be considered skin and respiratory sensitisers. The additive has the potential to be efficacious in laying hens at 1,000 U phytase/kg complete feed. The conclusion can be extrapolated to other birds for egg production or breeding. The FEEDAP Panel cannot conclude on the efficacy of all pigs or growing poultry species.
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spelling pubmed-97640372022-12-20 Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Brantom, Paul Dierick, Noël Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Casanova, Jordi Ortuño Pettenati, Elisa Tarrés‐Call, Jordi EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The additive VTR‐phytase consists of 6‐phytase and it is available in solid and liquid forms. VTR phytase (liquid/solid) was produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.370). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR phytase (liquid/solid) produced by Komagataella phaffii CGMCC 7.370 is safe for all Suidae and all avian species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid VTR phytase and powder VTR phytase are non‐irritant to skin or eyes but should be considered skin and respiratory sensitisers. The additive has the potential to be efficacious in laying hens at 1,000 U phytase/kg complete feed. The conclusion can be extrapolated to other birds for egg production or breeding. The FEEDAP Panel cannot conclude on the efficacy of all pigs or growing poultry species. John Wiley and Sons Inc. 2022-12-20 /pmc/articles/PMC9764037/ /pubmed/36545575 http://dx.doi.org/10.2903/j.efsa.2022.7701 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Fašmon Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
Puente, Secundino López
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Aquilina, Gabriele
Brantom, Paul
Dierick, Noël
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Casanova, Jordi Ortuño
Pettenati, Elisa
Tarrés‐Call, Jordi
Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title_full Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title_fullStr Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title_full_unstemmed Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title_short Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
title_sort safety and efficacy of a feed additive consisting of 6‐phytase produced by komagataella phaffii cgmcc 7.370 (vtr‐phytase powder/liquid) for all pigs and all avian species (victory enzymes gmbh)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764037/
https://www.ncbi.nlm.nih.gov/pubmed/36545575
http://dx.doi.org/10.2903/j.efsa.2022.7701
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