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Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH)
Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764037/ https://www.ncbi.nlm.nih.gov/pubmed/36545575 http://dx.doi.org/10.2903/j.efsa.2022.7701 |
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author | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Brantom, Paul Dierick, Noël Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Casanova, Jordi Ortuño Pettenati, Elisa Tarrés‐Call, Jordi |
author_facet | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Brantom, Paul Dierick, Noël Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Casanova, Jordi Ortuño Pettenati, Elisa Tarrés‐Call, Jordi |
collection | PubMed |
description | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The additive VTR‐phytase consists of 6‐phytase and it is available in solid and liquid forms. VTR phytase (liquid/solid) was produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.370). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR phytase (liquid/solid) produced by Komagataella phaffii CGMCC 7.370 is safe for all Suidae and all avian species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid VTR phytase and powder VTR phytase are non‐irritant to skin or eyes but should be considered skin and respiratory sensitisers. The additive has the potential to be efficacious in laying hens at 1,000 U phytase/kg complete feed. The conclusion can be extrapolated to other birds for egg production or breeding. The FEEDAP Panel cannot conclude on the efficacy of all pigs or growing poultry species. |
format | Online Article Text |
id | pubmed-9764037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97640372022-12-20 Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Brantom, Paul Dierick, Noël Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Casanova, Jordi Ortuño Pettenati, Elisa Tarrés‐Call, Jordi EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of 6‐phytase (VTR‐phytase) as zootechnical feed additive for all pigs and all avian species. The additive VTR‐phytase consists of 6‐phytase and it is available in solid and liquid forms. VTR phytase (liquid/solid) was produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.370). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR phytase (liquid/solid) produced by Komagataella phaffii CGMCC 7.370 is safe for all Suidae and all avian species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid VTR phytase and powder VTR phytase are non‐irritant to skin or eyes but should be considered skin and respiratory sensitisers. The additive has the potential to be efficacious in laying hens at 1,000 U phytase/kg complete feed. The conclusion can be extrapolated to other birds for egg production or breeding. The FEEDAP Panel cannot conclude on the efficacy of all pigs or growing poultry species. John Wiley and Sons Inc. 2022-12-20 /pmc/articles/PMC9764037/ /pubmed/36545575 http://dx.doi.org/10.2903/j.efsa.2022.7701 Text en © 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta Puente, Secundino López Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Aquilina, Gabriele Brantom, Paul Dierick, Noël Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Casanova, Jordi Ortuño Pettenati, Elisa Tarrés‐Call, Jordi Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title | Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii
CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title_full | Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii
CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title_fullStr | Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii
CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title_full_unstemmed | Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii
CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title_short | Safety and efficacy of a feed additive consisting of 6‐phytase produced by Komagataella phaffii
CGMCC 7.370 (VTR‐phytase powder/liquid) for all pigs and all avian species (Victory Enzymes GmbH) |
title_sort | safety and efficacy of a feed additive consisting of 6‐phytase produced by komagataella phaffii
cgmcc 7.370 (vtr‐phytase powder/liquid) for all pigs and all avian species (victory enzymes gmbh) |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764037/ https://www.ncbi.nlm.nih.gov/pubmed/36545575 http://dx.doi.org/10.2903/j.efsa.2022.7701 |
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