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Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)

Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden. The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucl...

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Autores principales: Guo, Cunliang, Chen, Yungang, Wang, Yuhe, Hao, Yanke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764052/
https://www.ncbi.nlm.nih.gov/pubmed/36569433
http://dx.doi.org/10.3892/etm.2022.11743
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author Guo, Cunliang
Chen, Yungang
Wang, Yuhe
Hao, Yanke
author_facet Guo, Cunliang
Chen, Yungang
Wang, Yuhe
Hao, Yanke
author_sort Guo, Cunliang
collection PubMed
description Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden. The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. Non-coding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, are key regulators of the aforementioned processes. ncRNAs are differentially expressed in tissues of the intervertebral disc between healthy individuals and patients and participate in the pathological progression of IDD via a complex pattern of gene regulation. However, the regulatory mechanisms of ncRNAs in IDD remain unclear. The present review summarizes the latest insights into the regulatory role of ncRNAs in IDD and sheds light on potentially novel therapeutic strategies for IDD that may be implemented in the future.
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spelling pubmed-97640522022-12-22 Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review) Guo, Cunliang Chen, Yungang Wang, Yuhe Hao, Yanke Exp Ther Med Review Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden. The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. Non-coding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, are key regulators of the aforementioned processes. ncRNAs are differentially expressed in tissues of the intervertebral disc between healthy individuals and patients and participate in the pathological progression of IDD via a complex pattern of gene regulation. However, the regulatory mechanisms of ncRNAs in IDD remain unclear. The present review summarizes the latest insights into the regulatory role of ncRNAs in IDD and sheds light on potentially novel therapeutic strategies for IDD that may be implemented in the future. D.A. Spandidos 2022-12-01 /pmc/articles/PMC9764052/ /pubmed/36569433 http://dx.doi.org/10.3892/etm.2022.11743 Text en Copyright: © Guo et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Guo, Cunliang
Chen, Yungang
Wang, Yuhe
Hao, Yanke
Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title_full Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title_fullStr Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title_full_unstemmed Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title_short Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review)
title_sort regulatory roles of noncoding rnas in intervertebral disc degeneration as potential therapeutic targets (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764052/
https://www.ncbi.nlm.nih.gov/pubmed/36569433
http://dx.doi.org/10.3892/etm.2022.11743
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