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Use of ubiquitous chromatin opening elements (UCOE) as tools to maintain transgene expression in biotechnology
Amongst the most important outputs of the biopharmaceutical industry are recombinant proteins, many of which are produced by integrating transgenes into the genomes of mammalian cells. However, expression is highly variable and can be unstable during prolonged culture. This is often due to epigeneti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764128/ https://www.ncbi.nlm.nih.gov/pubmed/36582439 http://dx.doi.org/10.1016/j.csbj.2022.11.059 |