Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule. Using Tn antigen as the model, a three-component vaccine (MPLA-Tn-KRN7000) containing the TLR4 ligand MPLA and the iNKT cell agonist KRN7000 was...

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Detalles Bibliográficos
Autores principales: Yang, Deying, Luo, Xiang, Lian, Qinghai, Gao, Lingqiang, Wang, Chengxin, Qi, Xiaoxiao, Zhang, Rong, Liu, Zhongqiu, Liao, Guochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764137/
https://www.ncbi.nlm.nih.gov/pubmed/36561989
http://dx.doi.org/10.1016/j.apsb.2022.05.028

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