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Nivolumab for malignant transformation of ovarian mature cystic teratoma
Mature cystic teratoma of the ovary (MCT) occasionally undergoes malignant transformation (MT) that is resistant to chemotherapy and has a poor prognosis. We experienced a case of clinically aggressive MCT-MT that invades surrounding organs and tissues. Although tumor was resected entirely, a rapid...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764164/ https://www.ncbi.nlm.nih.gov/pubmed/36560959 http://dx.doi.org/10.1016/j.gore.2022.101115 |
| _version_ | 1784853217568358400 |
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| author | Yoshimura, Kayoko Yamanoi, Koji Kanai, Masashi Okunomiya, Asuka Sagae, Yusuke Sunada, Masumi Taki, Mana Ukita, Masayo Chigusa, Yoshitsugu Horie, Akihito Yamaguchi, Ken Hamanishi, Junzo Minamiguchi, Sachiko Yamamoto, Noboru Muto, Manabu Mandai, Masaki |
| author_facet | Yoshimura, Kayoko Yamanoi, Koji Kanai, Masashi Okunomiya, Asuka Sagae, Yusuke Sunada, Masumi Taki, Mana Ukita, Masayo Chigusa, Yoshitsugu Horie, Akihito Yamaguchi, Ken Hamanishi, Junzo Minamiguchi, Sachiko Yamamoto, Noboru Muto, Manabu Mandai, Masaki |
| author_sort | Yoshimura, Kayoko |
| collection | PubMed |
| description | Mature cystic teratoma of the ovary (MCT) occasionally undergoes malignant transformation (MT) that is resistant to chemotherapy and has a poor prognosis. We experienced a case of clinically aggressive MCT-MT that invades surrounding organs and tissues. Although tumor was resected entirely, a rapid tumor recurrence occurred during postoperative chemotherapy (paclitaxel + ifosfamide + cisplatin). The results of comprehensive genomic profiling test performed early in the postoperative period showed a high tumor mutational burden of 23 mutations/Mb. Treatment with nivolumab monotherapy has promptly been initiated and has been very successful for more than one year. |
| format | Online Article Text |
| id | pubmed-9764164 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-97641642022-12-21 Nivolumab for malignant transformation of ovarian mature cystic teratoma Yoshimura, Kayoko Yamanoi, Koji Kanai, Masashi Okunomiya, Asuka Sagae, Yusuke Sunada, Masumi Taki, Mana Ukita, Masayo Chigusa, Yoshitsugu Horie, Akihito Yamaguchi, Ken Hamanishi, Junzo Minamiguchi, Sachiko Yamamoto, Noboru Muto, Manabu Mandai, Masaki Gynecol Oncol Rep Case Report Mature cystic teratoma of the ovary (MCT) occasionally undergoes malignant transformation (MT) that is resistant to chemotherapy and has a poor prognosis. We experienced a case of clinically aggressive MCT-MT that invades surrounding organs and tissues. Although tumor was resected entirely, a rapid tumor recurrence occurred during postoperative chemotherapy (paclitaxel + ifosfamide + cisplatin). The results of comprehensive genomic profiling test performed early in the postoperative period showed a high tumor mutational burden of 23 mutations/Mb. Treatment with nivolumab monotherapy has promptly been initiated and has been very successful for more than one year. Elsevier 2022-12-10 /pmc/articles/PMC9764164/ /pubmed/36560959 http://dx.doi.org/10.1016/j.gore.2022.101115 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Yoshimura, Kayoko Yamanoi, Koji Kanai, Masashi Okunomiya, Asuka Sagae, Yusuke Sunada, Masumi Taki, Mana Ukita, Masayo Chigusa, Yoshitsugu Horie, Akihito Yamaguchi, Ken Hamanishi, Junzo Minamiguchi, Sachiko Yamamoto, Noboru Muto, Manabu Mandai, Masaki Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title_full | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title_fullStr | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title_full_unstemmed | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title_short | Nivolumab for malignant transformation of ovarian mature cystic teratoma |
| title_sort | nivolumab for malignant transformation of ovarian mature cystic teratoma |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764164/ https://www.ncbi.nlm.nih.gov/pubmed/36560959 http://dx.doi.org/10.1016/j.gore.2022.101115 |
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