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Form and function of archaeal genomes
A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Portland Press Ltd.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764264/ https://www.ncbi.nlm.nih.gov/pubmed/36511238 http://dx.doi.org/10.1042/BST20221396 |
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author | Bell, Stephen D. |
author_facet | Bell, Stephen D. |
author_sort | Bell, Stephen D. |
collection | PubMed |
description | A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe recent advances in our understanding of chromosome architecture in the archaeal domain of life. Although much remains to be learned about the mechanistic details of archaeal chromosome organization, some general principles have emerged. At the 10–100 kb level, archaeal chromosomes have a conserved local organization reminiscent of bacterial genomes. In contrast, lineage-specific innovations appear to have imposed distinct large-scale architectural features. The ultimate functions of genomes are to store and to express genetic information. Gene expression profiles have been shown to influence chromosome architecture, thus their form follows function. However, local changes to chromosome conformation can also influence gene expression and therefore, in these instances, function follows form. |
format | Online Article Text |
id | pubmed-9764264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97642642022-12-20 Form and function of archaeal genomes Bell, Stephen D. Biochem Soc Trans Review Articles A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe recent advances in our understanding of chromosome architecture in the archaeal domain of life. Although much remains to be learned about the mechanistic details of archaeal chromosome organization, some general principles have emerged. At the 10–100 kb level, archaeal chromosomes have a conserved local organization reminiscent of bacterial genomes. In contrast, lineage-specific innovations appear to have imposed distinct large-scale architectural features. The ultimate functions of genomes are to store and to express genetic information. Gene expression profiles have been shown to influence chromosome architecture, thus their form follows function. However, local changes to chromosome conformation can also influence gene expression and therefore, in these instances, function follows form. Portland Press Ltd. 2022-12-16 2022-12-13 /pmc/articles/PMC9764264/ /pubmed/36511238 http://dx.doi.org/10.1042/BST20221396 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Articles Bell, Stephen D. Form and function of archaeal genomes |
title | Form and function of archaeal genomes |
title_full | Form and function of archaeal genomes |
title_fullStr | Form and function of archaeal genomes |
title_full_unstemmed | Form and function of archaeal genomes |
title_short | Form and function of archaeal genomes |
title_sort | form and function of archaeal genomes |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764264/ https://www.ncbi.nlm.nih.gov/pubmed/36511238 http://dx.doi.org/10.1042/BST20221396 |
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