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Form and function of archaeal genomes

A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe...

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Autor principal: Bell, Stephen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764264/
https://www.ncbi.nlm.nih.gov/pubmed/36511238
http://dx.doi.org/10.1042/BST20221396
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author Bell, Stephen D.
author_facet Bell, Stephen D.
author_sort Bell, Stephen D.
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description A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe recent advances in our understanding of chromosome architecture in the archaeal domain of life. Although much remains to be learned about the mechanistic details of archaeal chromosome organization, some general principles have emerged. At the 10–100 kb level, archaeal chromosomes have a conserved local organization reminiscent of bacterial genomes. In contrast, lineage-specific innovations appear to have imposed distinct large-scale architectural features. The ultimate functions of genomes are to store and to express genetic information. Gene expression profiles have been shown to influence chromosome architecture, thus their form follows function. However, local changes to chromosome conformation can also influence gene expression and therefore, in these instances, function follows form.
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spelling pubmed-97642642022-12-20 Form and function of archaeal genomes Bell, Stephen D. Biochem Soc Trans Review Articles A key maxim in modernist architecture is that ‘form follows function'. While modernist buildings are hopefully the product of intelligent design, the architectures of chromosomes have been sculpted by the forces of evolution over many thousands of generations. In the following, I will describe recent advances in our understanding of chromosome architecture in the archaeal domain of life. Although much remains to be learned about the mechanistic details of archaeal chromosome organization, some general principles have emerged. At the 10–100 kb level, archaeal chromosomes have a conserved local organization reminiscent of bacterial genomes. In contrast, lineage-specific innovations appear to have imposed distinct large-scale architectural features. The ultimate functions of genomes are to store and to express genetic information. Gene expression profiles have been shown to influence chromosome architecture, thus their form follows function. However, local changes to chromosome conformation can also influence gene expression and therefore, in these instances, function follows form. Portland Press Ltd. 2022-12-16 2022-12-13 /pmc/articles/PMC9764264/ /pubmed/36511238 http://dx.doi.org/10.1042/BST20221396 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Bell, Stephen D.
Form and function of archaeal genomes
title Form and function of archaeal genomes
title_full Form and function of archaeal genomes
title_fullStr Form and function of archaeal genomes
title_full_unstemmed Form and function of archaeal genomes
title_short Form and function of archaeal genomes
title_sort form and function of archaeal genomes
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764264/
https://www.ncbi.nlm.nih.gov/pubmed/36511238
http://dx.doi.org/10.1042/BST20221396
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