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Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin

[Image: see text] CYP105AS1 is a cytochrome P450 from Amycolatopsis orientalis that catalyzes monooxygenation of compactin to 6-epi-pravastatin. For fermentative production of the cholesterol-lowering drug pravastatin, the stereoselectivity of the enzyme needs to be inverted, which has been partiall...

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Detalles Bibliográficos
Autores principales:	Ashworth, Mark A., Bombino, Elvira, de Jong, René M., Wijma, Hein J., Janssen, Dick B., McLean, Kirsty J., Munro, Andrew W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764288/ https://www.ncbi.nlm.nih.gov/pubmed/36570080 http://dx.doi.org/10.1021/acscatal.2c03974

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