Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies,...

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Detalles Bibliográficos
Autores principales: Ju, Yi, Carreño, Juan Manuel, Simon, Viviana, Dawson, Kenneth, Krammer, Florian, Kent, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764299/
https://www.ncbi.nlm.nih.gov/pubmed/36539526
http://dx.doi.org/10.1038/s41577-022-00825-x
Descripción
Sumario:The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.

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