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Mechanism of Action of Flavin-Dependent Halogenases
[Image: see text] To rationally engineer the substrate scope and selectivity of flavin-dependent halogenases (FDHs), it is essential to first understand the reaction mechanism and substrate interactions in the active site. FDHs have long been known to achieve regioselectivity through an electrophili...
Autores principales: | Barker, Rhys D., Yu, Yuqi, De Maria, Leonardo, Johannissen, Linus O., Scrutton, Nigel S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764358/ https://www.ncbi.nlm.nih.gov/pubmed/36570077 http://dx.doi.org/10.1021/acscatal.2c05231 |
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