Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines

Copper-promoted dehydrosulfurative C–N cross-coupling of 3,4-dihydropyrimidin-1H-2-thione with amine accompanied by concomitant aromatization to generate 2-aryl(alkyl)aminopyrimidine derivatives is described. The reaction proceeded well with a wide range of thiono substrates and aryl/aliphatic amine...

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Autores principales: Le Pham, Ngoc Son, Kwon, Yujeong, Shin, Hyunik, Sohn, Jeong-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764426/
https://www.ncbi.nlm.nih.gov/pubmed/36605669
http://dx.doi.org/10.1039/d2ra05180j
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author Le Pham, Ngoc Son
Kwon, Yujeong
Shin, Hyunik
Sohn, Jeong-Hun
author_facet Le Pham, Ngoc Son
Kwon, Yujeong
Shin, Hyunik
Sohn, Jeong-Hun
author_sort Le Pham, Ngoc Son
collection PubMed
description Copper-promoted dehydrosulfurative C–N cross-coupling of 3,4-dihydropyrimidin-1H-2-thione with amine accompanied by concomitant aromatization to generate 2-aryl(alkyl)aminopyrimidine derivatives is described. The reaction proceeded well with a wide range of thiono substrates and aryl/aliphatic amines as the coupling partners, offering efficient access to biologically and pharmacologically valuable 2-aryl(alkyl)aminopyrimidines with rapid diversification.
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spelling pubmed-97644262023-01-04 Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines Le Pham, Ngoc Son Kwon, Yujeong Shin, Hyunik Sohn, Jeong-Hun RSC Adv Chemistry Copper-promoted dehydrosulfurative C–N cross-coupling of 3,4-dihydropyrimidin-1H-2-thione with amine accompanied by concomitant aromatization to generate 2-aryl(alkyl)aminopyrimidine derivatives is described. The reaction proceeded well with a wide range of thiono substrates and aryl/aliphatic amines as the coupling partners, offering efficient access to biologically and pharmacologically valuable 2-aryl(alkyl)aminopyrimidines with rapid diversification. The Royal Society of Chemistry 2022-12-20 /pmc/articles/PMC9764426/ /pubmed/36605669 http://dx.doi.org/10.1039/d2ra05180j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Le Pham, Ngoc Son
Kwon, Yujeong
Shin, Hyunik
Sohn, Jeong-Hun
Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title_full Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title_fullStr Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title_full_unstemmed Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title_short Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
title_sort copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764426/
https://www.ncbi.nlm.nih.gov/pubmed/36605669
http://dx.doi.org/10.1039/d2ra05180j
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