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Copper-promoted dehydrosulfurative carbon–nitrogen cross-coupling with concomitant aromatization for synthesis of 2-aminopyrimidines

Copper-promoted dehydrosulfurative C–N cross-coupling of 3,4-dihydropyrimidin-1H-2-thione with amine accompanied by concomitant aromatization to generate 2-aryl(alkyl)aminopyrimidine derivatives is described. The reaction proceeded well with a wide range of thiono substrates and aryl/aliphatic amine...

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Detalles Bibliográficos
Autores principales: Le Pham, Ngoc Son, Kwon, Yujeong, Shin, Hyunik, Sohn, Jeong-Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764426/
https://www.ncbi.nlm.nih.gov/pubmed/36605669
http://dx.doi.org/10.1039/d2ra05180j

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