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Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease

OBJECTIVE: The renal excretion function of patients with chronic kidney disease (CKD) is reduced, and the nervous system toxic reactions of antibiotics are prone to occur. The purpose of this study is to screen out some risk factors for patients with CKD to suffer from antibiotic-associated encephal...

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Autores principales: Wang, Hongling, Liu, Daquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764618/
https://www.ncbi.nlm.nih.gov/pubmed/36526324
http://dx.doi.org/10.1136/bmjopen-2022-064995
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author Wang, Hongling
Liu, Daquan
author_facet Wang, Hongling
Liu, Daquan
author_sort Wang, Hongling
collection PubMed
description OBJECTIVE: The renal excretion function of patients with chronic kidney disease (CKD) is reduced, and the nervous system toxic reactions of antibiotics are prone to occur. The purpose of this study is to screen out some risk factors for patients with CKD to suffer from antibiotic-associated encephalopathy (AAE). DESIGN: A case–control study. SETTING: A tertiary hospital in China. PARTICIPANTS: The medical records of patients who were hospitalised for CKD and infectious diseases in our hospital from January 2010 to December 2019. All patients used antibiotics to treat infectious diseases during hospitalisation. All patients were divided into two groups according to whether they developed AAE during hospitalisation. The patients with CKD without AAE were selected as the control group (n=120), and the patients with CKD with AAE were regarded as the AAE group (n=102). INTERVENTIONS: This study systematically analysed its clinical manifestations, laboratory examinations, prognosis, etc, and summarised the risk factors related to AAE in patients with CKD. PRIMARY OUTCOME: Screening risk factors of AAE in patients with CKD. RESULTS: Logistic regression analysis showed that coronary heart disease, as well as abnormal indicators of haemoglobin, albumin, uric acid and blood phosphorus were independent risk factors for patients with CKD with AAE (OR values were 4.137, 0.963, 0.849, 0.996 0.161, respectively, all p<0.05). The case fatality rate (Pearson χ(2)=7.524, p=0.006), rehospitalisation rate (Pearson χ(2)=6.187, p=0.013) and treatment costs (t=−8.44, p<0.001) in encephalopathy group are significantly higher than the control group. CONCLUSIONS: Patients with CKD with AAE will increase the case fatality rate and cause poor prognosis. Coronary heart disease, as well as decreased levels of haemoglobin, albumin, uric acid, and blood phosphorus are independent risk factors for patients with CKD with AAE. Timely intervention of these risk factors may reduce the incidence of AAE and improve the prognosis.
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spelling pubmed-97646182022-12-21 Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease Wang, Hongling Liu, Daquan BMJ Open Urology OBJECTIVE: The renal excretion function of patients with chronic kidney disease (CKD) is reduced, and the nervous system toxic reactions of antibiotics are prone to occur. The purpose of this study is to screen out some risk factors for patients with CKD to suffer from antibiotic-associated encephalopathy (AAE). DESIGN: A case–control study. SETTING: A tertiary hospital in China. PARTICIPANTS: The medical records of patients who were hospitalised for CKD and infectious diseases in our hospital from January 2010 to December 2019. All patients used antibiotics to treat infectious diseases during hospitalisation. All patients were divided into two groups according to whether they developed AAE during hospitalisation. The patients with CKD without AAE were selected as the control group (n=120), and the patients with CKD with AAE were regarded as the AAE group (n=102). INTERVENTIONS: This study systematically analysed its clinical manifestations, laboratory examinations, prognosis, etc, and summarised the risk factors related to AAE in patients with CKD. PRIMARY OUTCOME: Screening risk factors of AAE in patients with CKD. RESULTS: Logistic regression analysis showed that coronary heart disease, as well as abnormal indicators of haemoglobin, albumin, uric acid and blood phosphorus were independent risk factors for patients with CKD with AAE (OR values were 4.137, 0.963, 0.849, 0.996 0.161, respectively, all p<0.05). The case fatality rate (Pearson χ(2)=7.524, p=0.006), rehospitalisation rate (Pearson χ(2)=6.187, p=0.013) and treatment costs (t=−8.44, p<0.001) in encephalopathy group are significantly higher than the control group. CONCLUSIONS: Patients with CKD with AAE will increase the case fatality rate and cause poor prognosis. Coronary heart disease, as well as decreased levels of haemoglobin, albumin, uric acid, and blood phosphorus are independent risk factors for patients with CKD with AAE. Timely intervention of these risk factors may reduce the incidence of AAE and improve the prognosis. BMJ Publishing Group 2022-12-16 /pmc/articles/PMC9764618/ /pubmed/36526324 http://dx.doi.org/10.1136/bmjopen-2022-064995 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Urology
Wang, Hongling
Liu, Daquan
Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title_full Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title_fullStr Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title_full_unstemmed Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title_short Retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
title_sort retrospective case–control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease
topic Urology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764618/
https://www.ncbi.nlm.nih.gov/pubmed/36526324
http://dx.doi.org/10.1136/bmjopen-2022-064995
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