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The dynamic communities of oral microbiome in neonates

The oral microbiome, associated with both oral disease and systemic disease, is in dynamic status along the whole life, and many factors including maternal microbiomes could impact the oral microbiome. While fewer studies have been conducted to study the characteristics of the oral microbiome in neo...

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Autores principales: Guo, Haiying, Li, Jin, Yao, Hantao, Liu, Yina, Ji, Yaoting, Zhang, Jing, Zhao, Yun, Du, Minquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764626/
https://www.ncbi.nlm.nih.gov/pubmed/36560953
http://dx.doi.org/10.3389/fmicb.2022.1052525
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author Guo, Haiying
Li, Jin
Yao, Hantao
Liu, Yina
Ji, Yaoting
Zhang, Jing
Zhao, Yun
Du, Minquan
author_facet Guo, Haiying
Li, Jin
Yao, Hantao
Liu, Yina
Ji, Yaoting
Zhang, Jing
Zhao, Yun
Du, Minquan
author_sort Guo, Haiying
collection PubMed
description The oral microbiome, associated with both oral disease and systemic disease, is in dynamic status along the whole life, and many factors including maternal microbiomes could impact the oral microbiome. While fewer studies have been conducted to study the characteristics of the oral microbiome in neonates and the associated maternal factors. Hence, we collected the microbiome of 15 mother-infant pairs across multiple body sites from birth up to 4 days postpartum and used high-throughput sequencing to characterize the microbiomes in mothers and their neonates. The oral microbiome in the neonates changed obviously during the 4 days after birth. Many bacteria originating from the vagina, skin, and environment disappeared in oral cavity over time, such as Prevotella bivia and Prevotella jejuni. Meanwhile, Staphylococcus epidermidis RP62A phage SP-beta, predominate bacterium in maternal skin microbiome and Streptococcus unclassified, main bacterium in vaginal microbiome, obviously increased in neonatal oral microbiome as time went on. Interestingly, as time progressed, the composition of the oral microbiome in the neonates was more similar to that of the milk microbiome in their mothers. Moreover, we found that the changes in the predominant bacteria in the neonates were in line with those in the neonates exposed to the environment. Together, these data described the sharp dynamics of the oral microbiome in neonates and the importance of maternal efforts in the development of the neonatal microbiome.
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spelling pubmed-97646262022-12-21 The dynamic communities of oral microbiome in neonates Guo, Haiying Li, Jin Yao, Hantao Liu, Yina Ji, Yaoting Zhang, Jing Zhao, Yun Du, Minquan Front Microbiol Microbiology The oral microbiome, associated with both oral disease and systemic disease, is in dynamic status along the whole life, and many factors including maternal microbiomes could impact the oral microbiome. While fewer studies have been conducted to study the characteristics of the oral microbiome in neonates and the associated maternal factors. Hence, we collected the microbiome of 15 mother-infant pairs across multiple body sites from birth up to 4 days postpartum and used high-throughput sequencing to characterize the microbiomes in mothers and their neonates. The oral microbiome in the neonates changed obviously during the 4 days after birth. Many bacteria originating from the vagina, skin, and environment disappeared in oral cavity over time, such as Prevotella bivia and Prevotella jejuni. Meanwhile, Staphylococcus epidermidis RP62A phage SP-beta, predominate bacterium in maternal skin microbiome and Streptococcus unclassified, main bacterium in vaginal microbiome, obviously increased in neonatal oral microbiome as time went on. Interestingly, as time progressed, the composition of the oral microbiome in the neonates was more similar to that of the milk microbiome in their mothers. Moreover, we found that the changes in the predominant bacteria in the neonates were in line with those in the neonates exposed to the environment. Together, these data described the sharp dynamics of the oral microbiome in neonates and the importance of maternal efforts in the development of the neonatal microbiome. Frontiers Media S.A. 2022-12-06 /pmc/articles/PMC9764626/ /pubmed/36560953 http://dx.doi.org/10.3389/fmicb.2022.1052525 Text en Copyright © 2022 Guo, Li, Yao, Liu, Ji, Zhang, Zhao and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Guo, Haiying
Li, Jin
Yao, Hantao
Liu, Yina
Ji, Yaoting
Zhang, Jing
Zhao, Yun
Du, Minquan
The dynamic communities of oral microbiome in neonates
title The dynamic communities of oral microbiome in neonates
title_full The dynamic communities of oral microbiome in neonates
title_fullStr The dynamic communities of oral microbiome in neonates
title_full_unstemmed The dynamic communities of oral microbiome in neonates
title_short The dynamic communities of oral microbiome in neonates
title_sort dynamic communities of oral microbiome in neonates
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764626/
https://www.ncbi.nlm.nih.gov/pubmed/36560953
http://dx.doi.org/10.3389/fmicb.2022.1052525
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