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Acute Pancreatitis in Patients After Liver Transplantation

BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-...

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Autores principales: Hujova, Alzbeta, Macinga, Peter, Jarosova, Jana, Fronek, Jiri, Taimr, Pavel, Spicak, Julius, Hucl, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764668/
https://www.ncbi.nlm.nih.gov/pubmed/36523129
http://dx.doi.org/10.12659/AOT.938114
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author Hujova, Alzbeta
Macinga, Peter
Jarosova, Jana
Fronek, Jiri
Taimr, Pavel
Spicak, Julius
Hucl, Tomas
author_facet Hujova, Alzbeta
Macinga, Peter
Jarosova, Jana
Fronek, Jiri
Taimr, Pavel
Spicak, Julius
Hucl, Tomas
author_sort Hujova, Alzbeta
collection PubMed
description BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-volume transplant center. RESULTS: Out of a total of 1850 transplanted patients, 49 (2.8%) were diagnosed with AP. Of this group, 37 (75.5%) had a mild form of AP and 12 (24.5%) had a severe form of AP. The mortality rate was 10% overall and 42% in the group of patients with severe AP. An early form of AP (<30 days from transplantation) occurred in 13 patients (26.5%), most of whom presented with severe AP (10 patients, 76.9%); 4 patients died (40%). A late form of AP was diagnosed in 36 patients (73.5%), most of whom had mild AP (34 patients, 94.4%); 1 of 2 patients with severe AP died. The most common AP etiologies were post-ERCP (38.8%), idiopathic (34.7%), and postoperative (18.4%). Chronic HBV infection was a risk factor for development of AP (P=0.01). CONCLUSIONS: AP in liver transplant recipients was more frequent and more severe than in the general population. This unfavorable course was associated with the occurrence of AP in the early post-transplant period. Liver transplantation due to complications of HBV infection was a risk factor for the development of AP.
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spelling pubmed-97646682023-01-03 Acute Pancreatitis in Patients After Liver Transplantation Hujova, Alzbeta Macinga, Peter Jarosova, Jana Fronek, Jiri Taimr, Pavel Spicak, Julius Hucl, Tomas Ann Transplant Original Paper BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-volume transplant center. RESULTS: Out of a total of 1850 transplanted patients, 49 (2.8%) were diagnosed with AP. Of this group, 37 (75.5%) had a mild form of AP and 12 (24.5%) had a severe form of AP. The mortality rate was 10% overall and 42% in the group of patients with severe AP. An early form of AP (<30 days from transplantation) occurred in 13 patients (26.5%), most of whom presented with severe AP (10 patients, 76.9%); 4 patients died (40%). A late form of AP was diagnosed in 36 patients (73.5%), most of whom had mild AP (34 patients, 94.4%); 1 of 2 patients with severe AP died. The most common AP etiologies were post-ERCP (38.8%), idiopathic (34.7%), and postoperative (18.4%). Chronic HBV infection was a risk factor for development of AP (P=0.01). CONCLUSIONS: AP in liver transplant recipients was more frequent and more severe than in the general population. This unfavorable course was associated with the occurrence of AP in the early post-transplant period. Liver transplantation due to complications of HBV infection was a risk factor for the development of AP. International Scientific Literature, Inc. 2022-12-16 /pmc/articles/PMC9764668/ /pubmed/36523129 http://dx.doi.org/10.12659/AOT.938114 Text en © Ann Transplant, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Original Paper
Hujova, Alzbeta
Macinga, Peter
Jarosova, Jana
Fronek, Jiri
Taimr, Pavel
Spicak, Julius
Hucl, Tomas
Acute Pancreatitis in Patients After Liver Transplantation
title Acute Pancreatitis in Patients After Liver Transplantation
title_full Acute Pancreatitis in Patients After Liver Transplantation
title_fullStr Acute Pancreatitis in Patients After Liver Transplantation
title_full_unstemmed Acute Pancreatitis in Patients After Liver Transplantation
title_short Acute Pancreatitis in Patients After Liver Transplantation
title_sort acute pancreatitis in patients after liver transplantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764668/
https://www.ncbi.nlm.nih.gov/pubmed/36523129
http://dx.doi.org/10.12659/AOT.938114
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