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Acute Pancreatitis in Patients After Liver Transplantation
BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764668/ https://www.ncbi.nlm.nih.gov/pubmed/36523129 http://dx.doi.org/10.12659/AOT.938114 |
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author | Hujova, Alzbeta Macinga, Peter Jarosova, Jana Fronek, Jiri Taimr, Pavel Spicak, Julius Hucl, Tomas |
author_facet | Hujova, Alzbeta Macinga, Peter Jarosova, Jana Fronek, Jiri Taimr, Pavel Spicak, Julius Hucl, Tomas |
author_sort | Hujova, Alzbeta |
collection | PubMed |
description | BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-volume transplant center. RESULTS: Out of a total of 1850 transplanted patients, 49 (2.8%) were diagnosed with AP. Of this group, 37 (75.5%) had a mild form of AP and 12 (24.5%) had a severe form of AP. The mortality rate was 10% overall and 42% in the group of patients with severe AP. An early form of AP (<30 days from transplantation) occurred in 13 patients (26.5%), most of whom presented with severe AP (10 patients, 76.9%); 4 patients died (40%). A late form of AP was diagnosed in 36 patients (73.5%), most of whom had mild AP (34 patients, 94.4%); 1 of 2 patients with severe AP died. The most common AP etiologies were post-ERCP (38.8%), idiopathic (34.7%), and postoperative (18.4%). Chronic HBV infection was a risk factor for development of AP (P=0.01). CONCLUSIONS: AP in liver transplant recipients was more frequent and more severe than in the general population. This unfavorable course was associated with the occurrence of AP in the early post-transplant period. Liver transplantation due to complications of HBV infection was a risk factor for the development of AP. |
format | Online Article Text |
id | pubmed-9764668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97646682023-01-03 Acute Pancreatitis in Patients After Liver Transplantation Hujova, Alzbeta Macinga, Peter Jarosova, Jana Fronek, Jiri Taimr, Pavel Spicak, Julius Hucl, Tomas Ann Transplant Original Paper BACKGROUND: Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL/METHODS: The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-volume transplant center. RESULTS: Out of a total of 1850 transplanted patients, 49 (2.8%) were diagnosed with AP. Of this group, 37 (75.5%) had a mild form of AP and 12 (24.5%) had a severe form of AP. The mortality rate was 10% overall and 42% in the group of patients with severe AP. An early form of AP (<30 days from transplantation) occurred in 13 patients (26.5%), most of whom presented with severe AP (10 patients, 76.9%); 4 patients died (40%). A late form of AP was diagnosed in 36 patients (73.5%), most of whom had mild AP (34 patients, 94.4%); 1 of 2 patients with severe AP died. The most common AP etiologies were post-ERCP (38.8%), idiopathic (34.7%), and postoperative (18.4%). Chronic HBV infection was a risk factor for development of AP (P=0.01). CONCLUSIONS: AP in liver transplant recipients was more frequent and more severe than in the general population. This unfavorable course was associated with the occurrence of AP in the early post-transplant period. Liver transplantation due to complications of HBV infection was a risk factor for the development of AP. International Scientific Literature, Inc. 2022-12-16 /pmc/articles/PMC9764668/ /pubmed/36523129 http://dx.doi.org/10.12659/AOT.938114 Text en © Ann Transplant, 2022 https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Original Paper Hujova, Alzbeta Macinga, Peter Jarosova, Jana Fronek, Jiri Taimr, Pavel Spicak, Julius Hucl, Tomas Acute Pancreatitis in Patients After Liver Transplantation |
title | Acute Pancreatitis in Patients After Liver Transplantation |
title_full | Acute Pancreatitis in Patients After Liver Transplantation |
title_fullStr | Acute Pancreatitis in Patients After Liver Transplantation |
title_full_unstemmed | Acute Pancreatitis in Patients After Liver Transplantation |
title_short | Acute Pancreatitis in Patients After Liver Transplantation |
title_sort | acute pancreatitis in patients after liver transplantation |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764668/ https://www.ncbi.nlm.nih.gov/pubmed/36523129 http://dx.doi.org/10.12659/AOT.938114 |
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