Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to motor neuron degeneration. It has been proposed that epigenetic modification and transcriptional dysregulation may contribute to motor neuron death. In this study, we i...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Seung-Hye, Yousefian-Jazi, Ali, Hyeon, Seung Jae, Nguyen, Phuong Thi Thanh, Chu, Jiyeon, Kim, Sojung, Kim, Suhyun, Ryu, Hannah L., Kowall, Neil W., Ryu, Hoon, Lee, Junghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764677/
https://www.ncbi.nlm.nih.gov/pubmed/36536341
http://dx.doi.org/10.1186/s12929-022-00890-3

Ejemplares similares

Ejemplares similares