A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count

BACKGROUND: Chimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and potent T-cell-mediated cytotoxicity toward malignant cells. Despite several CAR-T products being approved and commercialized in the USA, Europe, and China, CAR-T products still requ...

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Detalles Bibliográficos
Autores principales: Wang, Haiying, Tsao, Shih-Ting, Gu, Mingyuan, Fu, Chengbing, He, Feng, Li, Xiu, Zhang, Mian, Li, Na, Hu, Hong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764707/
https://www.ncbi.nlm.nih.gov/pubmed/36536403
http://dx.doi.org/10.1186/s12967-022-03833-6

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