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Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinical anti-M. abscessus antibiotics. Due to its modera...
Autores principales: | Sarathy, Jickky Palmae, Zimmerman, Matthew D., Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765218/ https://www.ncbi.nlm.nih.gov/pubmed/36350151 http://dx.doi.org/10.1128/aac.01237-22 |
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