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Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro

The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target retention. OPC-167832 was bactericidal and did not antagonize activity of clinical anti-M. abscessus antibiotics. Due to its modera...

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Detalles Bibliográficos
Autores principales: Sarathy, Jickky Palmae, Zimmerman, Matthew D., Gengenbacher, Martin, Dartois, Véronique, Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765218/
https://www.ncbi.nlm.nih.gov/pubmed/36350151
http://dx.doi.org/10.1128/aac.01237-22

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