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Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2
BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide with global financial and health care systems consequences. It is already well recognized that immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a precondition for blocking mutations a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elmer Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765316/ https://www.ncbi.nlm.nih.gov/pubmed/36578371 http://dx.doi.org/10.14740/jocmr4821 |
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author | Lagadinou, Maria Eleftherakis, George Papageorgiou, Dimitris Chioni, Anastasia Paraskevas, Themistoklis Platanaki, Christina Marangos, Markos Velissaris, Dimitrios |
author_facet | Lagadinou, Maria Eleftherakis, George Papageorgiou, Dimitris Chioni, Anastasia Paraskevas, Themistoklis Platanaki, Christina Marangos, Markos Velissaris, Dimitrios |
author_sort | Lagadinou, Maria |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide with global financial and health care systems consequences. It is already well recognized that immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a precondition for blocking mutations and prevent the emergence of variants. The aim of the study was to investigate the possible relationship between COVID-19 vaccines and the commonly used disease-related blood biomarkers. METHODS: Adult patients with confirmed SARS-CoV-2 infection who were hospitalized from November 8, 2021, to December 31, 2021, were included. The retrospective study was conducted in Patras University Hospital, Greece. Two groups of patients were assessed, the ones who were previously vaccinated against SARS-CoV-2 (group A, n = 21), and those who were not (group B, n = 55). After analysis of peripheral blood, we calculated on admission day for each patient the total white blood cell (WBC), absolute lymphocytes count (ALC), absolute monocyte count, D-dimers, C-reactive protein (CRP) plasma levels, lactate dehydrogenase (LDH), ferritin, high-sensitive troponin, as well as the arterial oxygen partial pressure/fractional inspired oxygen (PO(2)/FiO(2)) ratio. RESULTS: The median age of all patients was 65.3 ± 15.2 years old; 68.4% were men and 31.6% were women. Comorbidities were present in 51 patients (67.1%). Hypertension and diabetes were observed as the most common comorbidities (33.3%). About 72.4% of the patients were unvaccinated or have received the first dose of vaccine, and 27.6% were completely vaccinated. No statistical difference was found in the total WBC count and ALC between the two groups (group A vs. group B: 8,168.95 ± 7,584.4 vs. 8,521.9 ± 6,571.3, P = 0.848 and 3,052.1 ± 7,230.7 vs. 1,279.6 ± 1,218.6, P = 0.087). Monocytes count in both groups did not show statistical difference: group A vs. group B: 672.6 ± 384.7 vs. 637.9 ± 477.8 (P = 0.754). Similarly, no difference for D-dimers (1,348.5 ± 1,397.6 vs. 1,850.9 ± 3,877.5, P = 0.575), ferritin (1,082.8 ± 1,399.5 vs. 1,327.4 ± 1,307.8, P = 0.508), high-sensitive troponin (113.6 ± 318.1 vs. 157.5 ± 48.8, P = 0.252), and CRP (6.92 ± 4.9 vs. 7.4 ± 5.9, P = 0.732). For LDH plasma levels, the statistical difference was significant (274.2 ± 85.6 vs. 387.5 ± 223.4, P = 0.003), as well as for the PO(2)/FiO(2) ratio (355.6 ± 129.7 vs. 260.5 ± 123.3, P = 0,006). CONCLUSIONS: In a mixed population hospitalized for COVID-19, only LDH plasma levels and the PaO(2)/FiO(2) on admission day showed statistically significant difference between vaccinated and unvaccinated patients. Although unvaccinated patients are more likely to develop severe illness, they did not express significantly higher values of commonly used plasma biomarkers such as ferritin, CRP, and D-dimers which are related to disease severity. |
format | Online Article Text |
id | pubmed-9765316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97653162022-12-27 Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 Lagadinou, Maria Eleftherakis, George Papageorgiou, Dimitris Chioni, Anastasia Paraskevas, Themistoklis Platanaki, Christina Marangos, Markos Velissaris, Dimitrios J Clin Med Res Short Communication BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide with global financial and health care systems consequences. It is already well recognized that immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a precondition for blocking mutations and prevent the emergence of variants. The aim of the study was to investigate the possible relationship between COVID-19 vaccines and the commonly used disease-related blood biomarkers. METHODS: Adult patients with confirmed SARS-CoV-2 infection who were hospitalized from November 8, 2021, to December 31, 2021, were included. The retrospective study was conducted in Patras University Hospital, Greece. Two groups of patients were assessed, the ones who were previously vaccinated against SARS-CoV-2 (group A, n = 21), and those who were not (group B, n = 55). After analysis of peripheral blood, we calculated on admission day for each patient the total white blood cell (WBC), absolute lymphocytes count (ALC), absolute monocyte count, D-dimers, C-reactive protein (CRP) plasma levels, lactate dehydrogenase (LDH), ferritin, high-sensitive troponin, as well as the arterial oxygen partial pressure/fractional inspired oxygen (PO(2)/FiO(2)) ratio. RESULTS: The median age of all patients was 65.3 ± 15.2 years old; 68.4% were men and 31.6% were women. Comorbidities were present in 51 patients (67.1%). Hypertension and diabetes were observed as the most common comorbidities (33.3%). About 72.4% of the patients were unvaccinated or have received the first dose of vaccine, and 27.6% were completely vaccinated. No statistical difference was found in the total WBC count and ALC between the two groups (group A vs. group B: 8,168.95 ± 7,584.4 vs. 8,521.9 ± 6,571.3, P = 0.848 and 3,052.1 ± 7,230.7 vs. 1,279.6 ± 1,218.6, P = 0.087). Monocytes count in both groups did not show statistical difference: group A vs. group B: 672.6 ± 384.7 vs. 637.9 ± 477.8 (P = 0.754). Similarly, no difference for D-dimers (1,348.5 ± 1,397.6 vs. 1,850.9 ± 3,877.5, P = 0.575), ferritin (1,082.8 ± 1,399.5 vs. 1,327.4 ± 1,307.8, P = 0.508), high-sensitive troponin (113.6 ± 318.1 vs. 157.5 ± 48.8, P = 0.252), and CRP (6.92 ± 4.9 vs. 7.4 ± 5.9, P = 0.732). For LDH plasma levels, the statistical difference was significant (274.2 ± 85.6 vs. 387.5 ± 223.4, P = 0.003), as well as for the PO(2)/FiO(2) ratio (355.6 ± 129.7 vs. 260.5 ± 123.3, P = 0,006). CONCLUSIONS: In a mixed population hospitalized for COVID-19, only LDH plasma levels and the PaO(2)/FiO(2) on admission day showed statistically significant difference between vaccinated and unvaccinated patients. Although unvaccinated patients are more likely to develop severe illness, they did not express significantly higher values of commonly used plasma biomarkers such as ferritin, CRP, and D-dimers which are related to disease severity. Elmer Press 2022-11 2022-11-29 /pmc/articles/PMC9765316/ /pubmed/36578371 http://dx.doi.org/10.14740/jocmr4821 Text en Copyright 2022, Lagadinou et al. https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Lagadinou, Maria Eleftherakis, George Papageorgiou, Dimitris Chioni, Anastasia Paraskevas, Themistoklis Platanaki, Christina Marangos, Markos Velissaris, Dimitrios Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title | Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title_full | Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title_fullStr | Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title_full_unstemmed | Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title_short | Alterations in Laboratory Parameters Related to Disease Severity in Vaccinated Patients Against SARS-CoV-2 |
title_sort | alterations in laboratory parameters related to disease severity in vaccinated patients against sars-cov-2 |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765316/ https://www.ncbi.nlm.nih.gov/pubmed/36578371 http://dx.doi.org/10.14740/jocmr4821 |
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