Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

Skin injury occurs due to acute trauma, chronic trauma, infection, and surgical intervention, which can result in severe dysfunction and even death in humans. Therefore, clinical intervention is critical for the treatment of skin wounds. One idealized method is to use wound dressings to protect skin wounds and promote wound healing. Among these wound dressings, nanocomposite natural polymer hydrogels (NNPHs) are multifunctional wound dressings for wound healing. The combination of nanomaterials and natural polymer hydrogels avoids the shortcomings of a single component. Moreover, nanomaterials could provide improved antibacterial, anti-inflammatory, antioxidant, stimuli-responsive, electrically conductive and mechanical properties of hydrogels to accelerate wound healing. This review focuses on recent advancements in NNPHs for skin wound healing and repair. Initially, the functions and requirements of NNPHs as wound dressings were introduced. Second, the design, preparation and capacities of representative NNPHs are classified based on their nanomaterial. Third, skin wound repair applications of NNPHs have been summarized based on the types of wounds. Finally, the potential issues of NNPHs are discussed, and future research is proposed to prepare idealized multifunctional NNPHs for skin tissue regeneration.