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Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States

Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP(8). IP(8) dynamics are determined by Asp1, a bifunctional enzyme consisting of an N-terminal kinase domain and a C-terminal pyro...

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Detalles Bibliográficos
Autores principales:	Benjamin, Bradley, Goldgur, Yehuda, Jork, Nikolaus, Jessen, Henning J., Schwer, Beate, Shuman, Stewart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765450/ https://www.ncbi.nlm.nih.gov/pubmed/36468882 http://dx.doi.org/10.1128/mbio.03087-22

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