Exposure to BA.4/5 S protein drives neutralization of Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5 in vaccine-experienced humans and mice

The SARS-CoV-2 Omicron variant and its sublineages show pronounced viral escape from neutralizing antibodies elicited by vaccination or prior SARS-CoV-2 variant infection owing to over 30 amino acid alterations within the spike (S) glycoprotein. Breakthrough infection of vaccinated individuals with...

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Autores principales: Muik, Alexander, Lui, Bonny Gaby, Bacher, Maren, Wallisch, Ann-Kathrin, Toker, Aras, Couto, Carla Iris Cadima, Güler, Alptekin, Mampilli, Veena, Schmitt, Geneva J., Mottl, Jonathan, Ziegenhals, Thomas, Fesser, Stephanie, Reinholz, Jonas, Wernig, Florian, Schraut, Karla-Gerlinde, Hefesha, Hossam, Cai, Hui, Yang, Qi, Walzer, Kerstin C., Grosser, Jessica, Strauss, Stefan, Finlayson, Andrew, Krüger, Kimberly, Ozhelvaci, Orkun, Grikscheit, Katharina, Kohmer, Niko, Ciesek, Sandra, Swanson, Kena A., Vogel, Annette B., Türeci, Özlem, Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765452/
https://www.ncbi.nlm.nih.gov/pubmed/36378074
http://dx.doi.org/10.1126/sciimmunol.ade9888

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