Cargando…

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

In parallel with vaccination, oral antiviral agents are highly anticipated to act as countermeasures for the treatment of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Oral antiviral medication demands not only high antiviral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasaki, Michihito, Tabata, Koshiro, Kishimoto, Mai, Itakura, Yukari, Kobayashi, Hiroko, Ariizumi, Takuma, Uemura, Kentaro, Toba, Shinsuke, Kusakabe, Shinji, Maruyama, Yuki, Iida, Shun, Nakajima, Noriko, Suzuki, Tadaki, Yoshida, Shinpei, Nobori, Haruaki, Sanaki, Takao, Kato, Teruhisa, Shishido, Takao, Hall, William W., Orba, Yasuko, Sato, Akihiko, Sawa, Hirofumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765455/ https://www.ncbi.nlm.nih.gov/pubmed/36327352 http://dx.doi.org/10.1126/scitranslmed.abq4064

Ejemplares similares

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19
por: Unoh, Yuto, et al.
Publicado: (2022)

Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells
por: Sasaki, Michihito, et al.
Publicado: (2021)

SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity
por: Sasaki, Michihito, et al.
Publicado: (2021)

5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
por: Uemura, Kentaro, et al.
Publicado: (2021)

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
por: Sasaki, Michihito, et al.
Publicado: (2021)

Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
por: Tabata, Koshiro, et al.
Publicado: (2023)

MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
por: Uemura, Kentaro, et al.
Publicado: (2021)

Host Serine Proteases TMPRSS2 and TMPRSS11D Mediate Proteolytic Activation and Trypsin-Independent Infection in Group A Rotaviruses
por: Sasaki, Michihito, et al.
Publicado: (2021)

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein
por: Kishimoto, Mai, et al.
Publicado: (2021)

2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
por: Uemura, Kentaro, et al.
Publicado: (2023)

A phase 2/3 study of S-217622 in participants with SARS-CoV-2 infection (Phase 3 part)
por: Yotsuyanagi, Hiroshi, et al.
Publicado: (2023)

Glu(333) in rabies virus glycoprotein is involved in virus attenuation through astrocyte infection and interferon responses
por: Itakura, Yukari, et al.
Publicado: (2022)

Pharmacokinetic and Pharmacodynamic Analysis of the 3CL Protease Inhibitor Ensitrelvir in a SARS-CoV-2 Infection Mouse Model
por: Fukao, Keita, et al.
Publicado: (2023)

Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses
por: Toba, Shinsuke, et al.
Publicado: (2022)

Characterization of the In Vitro and In Vivo Efficacy of Baloxavir Marboxil against H5 Highly Pathogenic Avian Influenza Virus Infection
por: Taniguchi, Keiichi, et al.
Publicado: (2022)

Isolation and Characterization of Distinct Rotavirus A in Bat and Rodent Hosts
por: Kishimoto, Mai, et al.
Publicado: (2023)

Morphogenesis of Bullet-Shaped Rabies Virus Particles Regulated by TSG101
por: Itakura, Yukari, et al.
Publicado: (2023)

Efficacy comparison of 3CL protease inhibitors ensitrelvir and nirmatrelvir against SARS-CoV-2 in vitro and in vivo
por: Kuroda, Takayuki, et al.
Publicado: (2023)

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2
por: Ohno, Marumi, et al.
Publicado: (2021)

A high-affinity aptamer with base-appended base-modified DNA bound to isolated authentic SARS-CoV-2 strains wild-type and B.1.617.2 (delta variant)
por: Minagawa, Hirotaka, et al.
Publicado: (2022)

Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines
por: Tazaki, Taiyu, et al.
Publicado: (2018)

Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil
por: Taniguchi, Keiichi, et al.
Publicado: (2019)

Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus
por: Phongphaew, Wallaya, et al.
Publicado: (2017)

Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2
por: Yang, Yujian, et al.
Publicado: (2023)

Role of the C-Terminal Region of Vervet Monkey Polyomavirus 1 VP1 in Virion Formation
por: YAMAGUCHI, Hiroki, et al.
Publicado: (2014)

LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19
por: Shimizu, Hideyuki, et al.
Publicado: (2022)

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin
por: Suzuki, Tadaki, et al.
Publicado: (2010)

Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation
por: Kobayashi, Shintaro, et al.
Publicado: (2013)

Distinct Lineages of Bufavirus in Wild Shrews and Nonhuman Primates
por: Sasaki, Michihito, et al.
Publicado: (2015)

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2
por: Takeda, Ryo, et al.
Publicado: (2022)

Two-stage one-pot synthetic strategy for the key triazone-triazole intermediate of ensitrelvir (S-217622), an oral clinical candidate for treating COVID-19
por: Hu, Wei, et al.
Publicado: (2022)

Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates
por: Anindita, Paulina D., et al.
Publicado: (2019)

Publisher Correction: Discovery and genetic characterization of diverse smacoviruses in Zambian non-human primates
por: Anindita, Paulina D., et al.
Publicado: (2019)

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
por: Yoo, Ji-Seung, et al.
Publicado: (2021)

Impact of Imprinted Immunity Induced by mRNA Vaccination in an Experimental Animal Model
por: Fujita, Shigeru, et al.
Publicado: (2023)

Human Parainfluenza Virus Type 3 in Wild Nonhuman Primates, Zambia
por: Sasaki, Michihito, et al.
Publicado: (2013)

Discoveries of Exoribonuclease-Resistant Structures of Insect-Specific Flaviviruses Isolated in Zambia
por: Wastika, Christida E., et al.
Publicado: (2020)

Ensitrelvir is effective against SARS-CoV-2 3CL protease mutants circulating globally
por: Kawashima, Sho, et al.
Publicado: (2023)

A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice
por: Ishii, Akihiro, et al.
Publicado: (2014)

Establishment of an immunoscreening system using recombinant VP1 protein for the isolation of a monoclonal antibody that blocks JC virus infection
por: Henmi, Chizuka, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_lefd71duvgko87tugd6i6cpjh7