SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

Numerous safe and effective COVID-19 vaccines have been developed worldwide that utilize various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S(1) s...

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Detalles Bibliográficos
Autores principales: Bowen, John E., Park, Young-Jun, Stewart, Cameron, Brown, Jack T., Sharkey, William K., Walls, Alexandra C., Joshi, Anshu, Sprouse, Kaitlin R., McCallum, Matthew, Tortorici, M. Alejandra, Franko, Nicholas M., Logue, Jennifer K., Mazzitelli, Ignacio G., Nguyen, Annalee W., Silva, Rui P., Huang, Yimin, Low, Jun Siong, Jerak, Josipa, Tiles, Sasha W, Ahmed, Kumail, Shariq, Asefa, Dan, Jennifer M., Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Snell, Gyorgy, Posavad, Christine M., Iqbal, Najeeha Talat, Geffner, Jorge, Bandera, Alessandra, Gori, Andrea, Sallusto, Federica, Maynard, Jennifer A., Crotty, Shane, Van Voorhis, Wesley C., Simmerling, Carlos, Grifantini, Renata, Chu, Helen Y., Corti, Davide, Veesler, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765460/
https://www.ncbi.nlm.nih.gov/pubmed/36356052
http://dx.doi.org/10.1126/sciimmunol.adf1421

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