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Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

In this study, an efficient nanobiocomposite based on graphene oxide (GO), carboxymethylcellulose (CMC) hydrogel, silk fibroin (SF), and Fe(3)O(4) nanoparticles was synthesized. For this purpose and in order to provide a suitable scaffold for the nanobiocomposite, GO was functionalized with a CMC hy...

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Autores principales: Ghafori Gorab, Mostafa, Aliabadi, Hooman Aghamirza Moghim, Kashtiaray, Amir, Mahdavi, Mohammad, Bani, Milad Salimi, Etminan, Andisheh, Salehpour, Nabi, Eivazzadeh-Keihan, Reza, Maleki, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765466/
https://www.ncbi.nlm.nih.gov/pubmed/36605797
http://dx.doi.org/10.1039/d2na00394e
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author Ghafori Gorab, Mostafa
Aliabadi, Hooman Aghamirza Moghim
Kashtiaray, Amir
Mahdavi, Mohammad
Bani, Milad Salimi
Etminan, Andisheh
Salehpour, Nabi
Eivazzadeh-Keihan, Reza
Maleki, Ali
author_facet Ghafori Gorab, Mostafa
Aliabadi, Hooman Aghamirza Moghim
Kashtiaray, Amir
Mahdavi, Mohammad
Bani, Milad Salimi
Etminan, Andisheh
Salehpour, Nabi
Eivazzadeh-Keihan, Reza
Maleki, Ali
author_sort Ghafori Gorab, Mostafa
collection PubMed
description In this study, an efficient nanobiocomposite based on graphene oxide (GO), carboxymethylcellulose (CMC) hydrogel, silk fibroin (SF), and Fe(3)O(4) nanoparticles was synthesized. For this purpose and in order to provide a suitable scaffold for the nanobiocomposite, GO was functionalized with a CMC hydrogel via covalent bonding. In the next step, SF was added to the synthesized structure to increase biocompatibility and biodegradability. Fe(3)O(4) was added into the structure by an in situ process and the GO–CMC hydrogel/SF/Fe(3)O(4) nanobiocomposite was synthesized. The synthesized structure was evaluated in terms of toxicity and hemocompatibility and finally, it was used in the hyperthermia technique. This nanocomposite did not destroy healthy HEK293T cells after 48 h and 72 h, while it did annihilate BT549 cancer cells. The GO–CMC hydrogel/SF/Fe(3)O(4) nanobiocomposite has EC50 values of 0.01466 and 0.1415 against HEK293T normal cells and BT549 cancer cells, respectively (after 72 h). The nanocomposite has good potential in hyperthermia applications and at a concentration and a frequency of 1 mg mL(−1) and 400 kHz it has a SAR of 67.7 W g(−1).
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spelling pubmed-97654662023-01-04 Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications Ghafori Gorab, Mostafa Aliabadi, Hooman Aghamirza Moghim Kashtiaray, Amir Mahdavi, Mohammad Bani, Milad Salimi Etminan, Andisheh Salehpour, Nabi Eivazzadeh-Keihan, Reza Maleki, Ali Nanoscale Adv Chemistry In this study, an efficient nanobiocomposite based on graphene oxide (GO), carboxymethylcellulose (CMC) hydrogel, silk fibroin (SF), and Fe(3)O(4) nanoparticles was synthesized. For this purpose and in order to provide a suitable scaffold for the nanobiocomposite, GO was functionalized with a CMC hydrogel via covalent bonding. In the next step, SF was added to the synthesized structure to increase biocompatibility and biodegradability. Fe(3)O(4) was added into the structure by an in situ process and the GO–CMC hydrogel/SF/Fe(3)O(4) nanobiocomposite was synthesized. The synthesized structure was evaluated in terms of toxicity and hemocompatibility and finally, it was used in the hyperthermia technique. This nanocomposite did not destroy healthy HEK293T cells after 48 h and 72 h, while it did annihilate BT549 cancer cells. The GO–CMC hydrogel/SF/Fe(3)O(4) nanobiocomposite has EC50 values of 0.01466 and 0.1415 against HEK293T normal cells and BT549 cancer cells, respectively (after 72 h). The nanocomposite has good potential in hyperthermia applications and at a concentration and a frequency of 1 mg mL(−1) and 400 kHz it has a SAR of 67.7 W g(−1). RSC 2022-11-14 /pmc/articles/PMC9765466/ /pubmed/36605797 http://dx.doi.org/10.1039/d2na00394e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ghafori Gorab, Mostafa
Aliabadi, Hooman Aghamirza Moghim
Kashtiaray, Amir
Mahdavi, Mohammad
Bani, Milad Salimi
Etminan, Andisheh
Salehpour, Nabi
Eivazzadeh-Keihan, Reza
Maleki, Ali
Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title_full Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title_fullStr Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title_full_unstemmed Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title_short Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
title_sort decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765466/
https://www.ncbi.nlm.nih.gov/pubmed/36605797
http://dx.doi.org/10.1039/d2na00394e
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