The Remarkable Genetics of Helicobacter pylori

The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22...

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Detalles Bibliográficos
Autor principal: Falush, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765472/
https://www.ncbi.nlm.nih.gov/pubmed/36286549
http://dx.doi.org/10.1128/mbio.02158-22
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author Falush, Daniel
author_facet Falush, Daniel
author_sort Falush, Daniel
collection PubMed
description The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22) helps to elucidate the cellular machinery that is used to achieve these unusual rates of genetic exchange. Specifically, they show that the UvrC gene, which is part of the repair machinery for DNA damage caused by ultraviolet light, has evolved an additional function in H. pylori, allowing very short tracts of DNA—with a mean length of only 28 bp—to be imported into the genome during natural transformation.
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spelling pubmed-97654722022-12-21 The Remarkable Genetics of Helicobacter pylori Falush, Daniel mBio Commentary The Helicobacter pylori genome is more thoroughly mixed by homologous recombination than by any other organism that has been investigated, leading to apparent “free recombination” within populations. A recent mBio article by F. Ailloud, I. Estibariz, G. Pfaffinger, and S. Suerbaum (mBio 13:e01811-22, 2022, https://doi.org/10.1128/mbio.01811-22) helps to elucidate the cellular machinery that is used to achieve these unusual rates of genetic exchange. Specifically, they show that the UvrC gene, which is part of the repair machinery for DNA damage caused by ultraviolet light, has evolved an additional function in H. pylori, allowing very short tracts of DNA—with a mean length of only 28 bp—to be imported into the genome during natural transformation. American Society for Microbiology 2022-10-26 /pmc/articles/PMC9765472/ /pubmed/36286549 http://dx.doi.org/10.1128/mbio.02158-22 Text en Copyright © 2022 Falush. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Falush, Daniel
The Remarkable Genetics of Helicobacter pylori
title The Remarkable Genetics of Helicobacter pylori
title_full The Remarkable Genetics of Helicobacter pylori
title_fullStr The Remarkable Genetics of Helicobacter pylori
title_full_unstemmed The Remarkable Genetics of Helicobacter pylori
title_short The Remarkable Genetics of Helicobacter pylori
title_sort remarkable genetics of helicobacter pylori
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765472/
https://www.ncbi.nlm.nih.gov/pubmed/36286549
http://dx.doi.org/10.1128/mbio.02158-22
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