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Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824
In a recent paper in Nanoscale Advances, Digiacomo et al. conclude that centrifugation should be the method of choice for researchers who want to investigate the protein corona of liposomes for drug delivery in human plasma. In this Comment, we however propose the opposite – that centrifugation, in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
RSC
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765536/ https://www.ncbi.nlm.nih.gov/pubmed/36605796 http://dx.doi.org/10.1039/d2na00343k |
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author | Münter, Rasmus Simonsen, Jens B. |
author_facet | Münter, Rasmus Simonsen, Jens B. |
author_sort | Münter, Rasmus |
collection | PubMed |
description | In a recent paper in Nanoscale Advances, Digiacomo et al. conclude that centrifugation should be the method of choice for researchers who want to investigate the protein corona of liposomes for drug delivery in human plasma. In this Comment, we however propose the opposite – that centrifugation, in most cases, is unsuitable for isolating liposomes from human plasma. Our conclusion is based on the bulk literature on this and similar topics, and new experimental data based on formulations and protocols like the ones used by Digiacomo et al. |
format | Online Article Text |
id | pubmed-9765536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | RSC |
record_format | MEDLINE/PubMed |
spelling | pubmed-97655362023-01-04 Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 Münter, Rasmus Simonsen, Jens B. Nanoscale Adv Chemistry In a recent paper in Nanoscale Advances, Digiacomo et al. conclude that centrifugation should be the method of choice for researchers who want to investigate the protein corona of liposomes for drug delivery in human plasma. In this Comment, we however propose the opposite – that centrifugation, in most cases, is unsuitable for isolating liposomes from human plasma. Our conclusion is based on the bulk literature on this and similar topics, and new experimental data based on formulations and protocols like the ones used by Digiacomo et al. RSC 2022-11-30 /pmc/articles/PMC9765536/ /pubmed/36605796 http://dx.doi.org/10.1039/d2na00343k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Münter, Rasmus Simonsen, Jens B. Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title | Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title_full | Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title_fullStr | Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title_full_unstemmed | Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title_short | Comment on “Optimal centrifugal isolating of liposome–protein complexes from human plasma” by L. Digiacomo, F. Giulimondi, A. L. Capriotti, S. Piovesana, C. M. Montone, R. Z. Chiozzi, A. Laganá, M. Mahmoudi, D. Pozzi and G. Caracciolo, Nanoscale Adv., 2021, 3, 3824 |
title_sort | comment on “optimal centrifugal isolating of liposome–protein complexes from human plasma” by l. digiacomo, f. giulimondi, a. l. capriotti, s. piovesana, c. m. montone, r. z. chiozzi, a. laganá, m. mahmoudi, d. pozzi and g. caracciolo, nanoscale adv., 2021, 3, 3824 |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765536/ https://www.ncbi.nlm.nih.gov/pubmed/36605796 http://dx.doi.org/10.1039/d2na00343k |
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