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Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis

The cytotoxic granules of human NK and CD8 T cells contain the effector molecule granulysin. Although in vitro studies indicate that granulysin is bactericidal to Mycobacterium tuberculosis and human CD8 T cells restrict intracellular M. tuberculosis by granule exocytosis, the role of granulysin in...

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Detalles Bibliográficos
Autores principales:	Thakur, Preeti, Sutiwisesak, Rujapak, Lu, Yu-Jung, Behar, Samuel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765553/ https://www.ncbi.nlm.nih.gov/pubmed/36409085 http://dx.doi.org/10.1128/mbio.03020-22

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