The Glymphatic System: a Potential Key Player in Bacterial Meningitis

The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S....

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Detalles Bibliográficos
Autores principales: Oggioni, Marco Rinaldo, Koedel, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765658/
https://www.ncbi.nlm.nih.gov/pubmed/36286550
http://dx.doi.org/10.1128/mbio.02350-22
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author Oggioni, Marco Rinaldo
Koedel, Uwe
author_facet Oggioni, Marco Rinaldo
Koedel, Uwe
author_sort Oggioni, Marco Rinaldo
collection PubMed
description The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S. Generoso, S. Thorsdottir, A. Collodel, R. R. E. Santo, et al. (mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22) have now associated impaired glymphatic system functionality to neurological sequelae of murine meningitis caused by Streptococcus pneumoniae. Their work provides an initial and important step into the systematic evaluation of a potential impact of glymphatic system functionality on disease severity and sequelae in meningitis.
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spelling pubmed-97656582022-12-21 The Glymphatic System: a Potential Key Player in Bacterial Meningitis Oggioni, Marco Rinaldo Koedel, Uwe mBio Commentary The glial-lymphatic system (glymphatic system) is a recently characterized fluid clearance pathway of the central nervous system. Glymphatic system disfunctions leading to defects in drainage of the cerebrospinal fluid have been associated with several neurological disorders. In their article, J. S. Generoso, S. Thorsdottir, A. Collodel, R. R. E. Santo, et al. (mBio 13:e01886-22, 2022, https://doi.org/10.1128/mBio.01886-22) have now associated impaired glymphatic system functionality to neurological sequelae of murine meningitis caused by Streptococcus pneumoniae. Their work provides an initial and important step into the systematic evaluation of a potential impact of glymphatic system functionality on disease severity and sequelae in meningitis. American Society for Microbiology 2022-10-26 /pmc/articles/PMC9765658/ /pubmed/36286550 http://dx.doi.org/10.1128/mbio.02350-22 Text en Copyright © 2022 Oggioni and Koedel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Oggioni, Marco Rinaldo
Koedel, Uwe
The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title_full The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title_fullStr The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title_full_unstemmed The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title_short The Glymphatic System: a Potential Key Player in Bacterial Meningitis
title_sort glymphatic system: a potential key player in bacterial meningitis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765658/
https://www.ncbi.nlm.nih.gov/pubmed/36286550
http://dx.doi.org/10.1128/mbio.02350-22
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