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PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS

To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spec...

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Autores principales: Mau, Theresa, Coen, Paul, Kritchevsky, Stephen, Newman, Anne, Distefano, Giovanna, Hepple, Russell T, Goodpaster, Bret, Cummings, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765757/
http://dx.doi.org/10.1093/geroni/igac059.833
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author Mau, Theresa
Coen, Paul
Kritchevsky, Stephen
Newman, Anne
Distefano, Giovanna
Hepple, Russell T
Goodpaster, Bret
Cummings, Steven
author_facet Mau, Theresa
Coen, Paul
Kritchevsky, Stephen
Newman, Anne
Distefano, Giovanna
Hepple, Russell T
Goodpaster, Bret
Cummings, Steven
author_sort Mau, Theresa
collection PubMed
description To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spectroscopy (n=468, mean=76.9yr). Max OXPHOS was strongly associated with leg power (β= 10.7 Watts per 1 SD increment, p<0.001) and peak VO2 (β= 83.7 mL/min, p<0.001). ATPmax had weak associations with leg power (β= 4.2 Watts per SD increment, p=0.13). In contrast to its weaker relationship with leg power, ATPmax was strongly associated with VO2 peak (β= 70.1 mL/min per SD increment, p<0.001). Skeletal muscle mitochondrial energetics were significant determinants of leg power and VO2 peak in older adults.
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spelling pubmed-97657572022-12-20 PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS Mau, Theresa Coen, Paul Kritchevsky, Stephen Newman, Anne Distefano, Giovanna Hepple, Russell T Goodpaster, Bret Cummings, Steven Innov Aging Abstracts To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spectroscopy (n=468, mean=76.9yr). Max OXPHOS was strongly associated with leg power (β= 10.7 Watts per 1 SD increment, p<0.001) and peak VO2 (β= 83.7 mL/min, p<0.001). ATPmax had weak associations with leg power (β= 4.2 Watts per SD increment, p=0.13). In contrast to its weaker relationship with leg power, ATPmax was strongly associated with VO2 peak (β= 70.1 mL/min per SD increment, p<0.001). Skeletal muscle mitochondrial energetics were significant determinants of leg power and VO2 peak in older adults. Oxford University Press 2022-12-20 /pmc/articles/PMC9765757/ http://dx.doi.org/10.1093/geroni/igac059.833 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Mau, Theresa
Coen, Paul
Kritchevsky, Stephen
Newman, Anne
Distefano, Giovanna
Hepple, Russell T
Goodpaster, Bret
Cummings, Steven
PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title_full PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title_fullStr PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title_full_unstemmed PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title_short PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
title_sort preliminary somma data: mitochondrial energetics, leg power, and cardiorespiratory fitness
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765757/
http://dx.doi.org/10.1093/geroni/igac059.833
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