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PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS
To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765757/ http://dx.doi.org/10.1093/geroni/igac059.833 |
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author | Mau, Theresa Coen, Paul Kritchevsky, Stephen Newman, Anne Distefano, Giovanna Hepple, Russell T Goodpaster, Bret Cummings, Steven |
author_facet | Mau, Theresa Coen, Paul Kritchevsky, Stephen Newman, Anne Distefano, Giovanna Hepple, Russell T Goodpaster, Bret Cummings, Steven |
author_sort | Mau, Theresa |
collection | PubMed |
description | To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spectroscopy (n=468, mean=76.9yr). Max OXPHOS was strongly associated with leg power (β= 10.7 Watts per 1 SD increment, p<0.001) and peak VO2 (β= 83.7 mL/min, p<0.001). ATPmax had weak associations with leg power (β= 4.2 Watts per SD increment, p=0.13). In contrast to its weaker relationship with leg power, ATPmax was strongly associated with VO2 peak (β= 70.1 mL/min per SD increment, p<0.001). Skeletal muscle mitochondrial energetics were significant determinants of leg power and VO2 peak in older adults. |
format | Online Article Text |
id | pubmed-9765757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-97657572022-12-20 PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS Mau, Theresa Coen, Paul Kritchevsky, Stephen Newman, Anne Distefano, Giovanna Hepple, Russell T Goodpaster, Bret Cummings, Steven Innov Aging Abstracts To assess mitochondrial function, max OXPHOS (maximal complex I and II supported state 3 respiration) was determined in vitro by high-resolution respirometry of permeabilized muscle fibers from thigh muscle (vastus lateralis) biopsies, and ATPmax was determined in vivo by 31P magnetic resonance spectroscopy (n=468, mean=76.9yr). Max OXPHOS was strongly associated with leg power (β= 10.7 Watts per 1 SD increment, p<0.001) and peak VO2 (β= 83.7 mL/min, p<0.001). ATPmax had weak associations with leg power (β= 4.2 Watts per SD increment, p=0.13). In contrast to its weaker relationship with leg power, ATPmax was strongly associated with VO2 peak (β= 70.1 mL/min per SD increment, p<0.001). Skeletal muscle mitochondrial energetics were significant determinants of leg power and VO2 peak in older adults. Oxford University Press 2022-12-20 /pmc/articles/PMC9765757/ http://dx.doi.org/10.1093/geroni/igac059.833 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstracts Mau, Theresa Coen, Paul Kritchevsky, Stephen Newman, Anne Distefano, Giovanna Hepple, Russell T Goodpaster, Bret Cummings, Steven PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title | PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title_full | PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title_fullStr | PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title_full_unstemmed | PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title_short | PRELIMINARY SOMMA DATA: MITOCHONDRIAL ENERGETICS, LEG POWER, AND CARDIORESPIRATORY FITNESS |
title_sort | preliminary somma data: mitochondrial energetics, leg power, and cardiorespiratory fitness |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765757/ http://dx.doi.org/10.1093/geroni/igac059.833 |
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