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JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING

Social isolation and loneliness (SI/L) are associated with a variety of physical and mental health conditions. Biological aging is a proposed mechanism through which psychosocial factors drive health disparities. However, it is not known how SI/L separately and jointly affect biological aging. Using...

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Autores principales: Qi, Xiang, Belsky, Daniel, Yang, Yang, Ng, Ted, Wu, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765840/
http://dx.doi.org/10.1093/geroni/igac059.715
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author Qi, Xiang
Belsky, Daniel
Yang, Yang
Ng, Ted
Wu, Bei
author_facet Qi, Xiang
Belsky, Daniel
Yang, Yang
Ng, Ted
Wu, Bei
author_sort Qi, Xiang
collection PubMed
description Social isolation and loneliness (SI/L) are associated with a variety of physical and mental health conditions. Biological aging is a proposed mechanism through which psychosocial factors drive health disparities. However, it is not known how SI/L separately and jointly affect biological aging. Using longitudinal data (N=1,965 adults, aged 50+) in Health and Retirement Study (2006 to 2016), we tested the joint trajectories of SI/L and their differential effects on biological aging as quantified by five DNA Methylation clocks (Horvath, Hannum, PhenoAge, GrimAge, and DunedinPoAm). A group-based mixture modeling approach was used to fit the joint trajectories of SI/L. Biological aging was measured using residuals from regressing each clock on chronological age. Linear regressions were used to test associations of joint trajectories of SI/L with biological aging. Four SI/L trajectories were identified, including Rarely isolated and rarely lonely (47.8%), Moderately isolated and rarely lonely (15.5%), Rarely isolated and severely lonely (20.2%), and Persistently isolated and lonely (16.5%). Of all joint trajectory groups, the Rarely isolated and rarely lonely group had the youngest biological age as estimated by the Hannum, PhenoAge, and GrimAge clocks. Compared with the Rarely isolated and severely lonely group, the Moderately isolated and rarely lonely group had higher age acceleration for PhenoAge (β=0.10; 95% CI=0.01, 0.19), and GrimAge (β=0.20; 95% CI=0.06,0.33), and DunedinPoAm (β=0.21; 95% CI=0.09,0.33). Different trajectories of SI/L convey differential risks to biological aging. Future research is needed to investigate the differences and similarities of SI/L trajectories and identify intervention targets for ameliorating aging.
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spelling pubmed-97658402022-12-20 JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING Qi, Xiang Belsky, Daniel Yang, Yang Ng, Ted Wu, Bei Innov Aging Abstracts Social isolation and loneliness (SI/L) are associated with a variety of physical and mental health conditions. Biological aging is a proposed mechanism through which psychosocial factors drive health disparities. However, it is not known how SI/L separately and jointly affect biological aging. Using longitudinal data (N=1,965 adults, aged 50+) in Health and Retirement Study (2006 to 2016), we tested the joint trajectories of SI/L and their differential effects on biological aging as quantified by five DNA Methylation clocks (Horvath, Hannum, PhenoAge, GrimAge, and DunedinPoAm). A group-based mixture modeling approach was used to fit the joint trajectories of SI/L. Biological aging was measured using residuals from regressing each clock on chronological age. Linear regressions were used to test associations of joint trajectories of SI/L with biological aging. Four SI/L trajectories were identified, including Rarely isolated and rarely lonely (47.8%), Moderately isolated and rarely lonely (15.5%), Rarely isolated and severely lonely (20.2%), and Persistently isolated and lonely (16.5%). Of all joint trajectory groups, the Rarely isolated and rarely lonely group had the youngest biological age as estimated by the Hannum, PhenoAge, and GrimAge clocks. Compared with the Rarely isolated and severely lonely group, the Moderately isolated and rarely lonely group had higher age acceleration for PhenoAge (β=0.10; 95% CI=0.01, 0.19), and GrimAge (β=0.20; 95% CI=0.06,0.33), and DunedinPoAm (β=0.21; 95% CI=0.09,0.33). Different trajectories of SI/L convey differential risks to biological aging. Future research is needed to investigate the differences and similarities of SI/L trajectories and identify intervention targets for ameliorating aging. Oxford University Press 2022-12-20 /pmc/articles/PMC9765840/ http://dx.doi.org/10.1093/geroni/igac059.715 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Qi, Xiang
Belsky, Daniel
Yang, Yang
Ng, Ted
Wu, Bei
JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title_full JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title_fullStr JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title_full_unstemmed JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title_short JOINT TRAJECTORIES OF SOCIAL ISOLATION AND LONELINESS AND THEIR EFFECTS ON ACCELERATED BIOLOGICAL AGING
title_sort joint trajectories of social isolation and loneliness and their effects on accelerated biological aging
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9765840/
http://dx.doi.org/10.1093/geroni/igac059.715
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