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METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE

When confronted with a major physical stressor, some older adults are able to recover to baseline with minimal changes, while others undergo irreversible declines. The ability to adapt and recover well from physical stress is called physical resilience and may be impeded by altered glucose-insulin d...

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Autores principales: Kalyani, Rita, Varadhan, Ravi, Xue, Qian-Li, Sieber, Frederick, Imus, Philip, Buta, Brian, Bandeen-Roche, Karen, Walston, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766107/
http://dx.doi.org/10.1093/geroni/igac059.008
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author Kalyani, Rita
Varadhan, Ravi
Xue, Qian-Li
Sieber, Frederick
Imus, Philip
Buta, Brian
Bandeen-Roche, Karen
Walston, Jeremy
author_facet Kalyani, Rita
Varadhan, Ravi
Xue, Qian-Li
Sieber, Frederick
Imus, Philip
Buta, Brian
Bandeen-Roche, Karen
Walston, Jeremy
author_sort Kalyani, Rita
collection PubMed
description When confronted with a major physical stressor, some older adults are able to recover to baseline with minimal changes, while others undergo irreversible declines. The ability to adapt and recover well from physical stress is called physical resilience and may be impeded by altered glucose-insulin dynamics. Among 55 participants in the pilot phase of the Study of Physical Resilience IN Geriatrics(SPRING), we examined associations between metabolic syndrome and/or diabetes status to physical resiliency recovery parameters after the clinical stressors total knee replacement and bone marrow transplant. These parameters included health outcomes, functional recovery, and pain in the weeks after the intervention. Additionally, we hypothesized that less resilient individuals would have abnormal glucose and insulin responses to a 75-gram oral glucose tolerance test at 0, 30, 60, 120 minutes and tested this in a subset (n=40) without known diabetes. Exploratory analyses of this pilot study will be presented during this session.
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spelling pubmed-97661072022-12-20 METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE Kalyani, Rita Varadhan, Ravi Xue, Qian-Li Sieber, Frederick Imus, Philip Buta, Brian Bandeen-Roche, Karen Walston, Jeremy Innov Aging Abstracts When confronted with a major physical stressor, some older adults are able to recover to baseline with minimal changes, while others undergo irreversible declines. The ability to adapt and recover well from physical stress is called physical resilience and may be impeded by altered glucose-insulin dynamics. Among 55 participants in the pilot phase of the Study of Physical Resilience IN Geriatrics(SPRING), we examined associations between metabolic syndrome and/or diabetes status to physical resiliency recovery parameters after the clinical stressors total knee replacement and bone marrow transplant. These parameters included health outcomes, functional recovery, and pain in the weeks after the intervention. Additionally, we hypothesized that less resilient individuals would have abnormal glucose and insulin responses to a 75-gram oral glucose tolerance test at 0, 30, 60, 120 minutes and tested this in a subset (n=40) without known diabetes. Exploratory analyses of this pilot study will be presented during this session. Oxford University Press 2022-12-20 /pmc/articles/PMC9766107/ http://dx.doi.org/10.1093/geroni/igac059.008 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
Kalyani, Rita
Varadhan, Ravi
Xue, Qian-Li
Sieber, Frederick
Imus, Philip
Buta, Brian
Bandeen-Roche, Karen
Walston, Jeremy
METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title_full METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title_fullStr METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title_full_unstemmed METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title_short METABOLIC SYNDROME, GLUCOSE INTOLERANCE, AND PHYSICAL RESILIENCE
title_sort metabolic syndrome, glucose intolerance, and physical resilience
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766107/
http://dx.doi.org/10.1093/geroni/igac059.008
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