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Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes
PURPOSE: To investigate potential associations between renal function and age-related macular degeneration (AMD) features as assessed with multimodal retinal imaging. METHODS: A subset of participants included in a dark adaptation study with varying AMD severities had estimated glomerular filtration...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766786/ https://www.ncbi.nlm.nih.gov/pubmed/36525252 http://dx.doi.org/10.1167/tvst.11.12.11 |
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author | Dave, Amisha D. Hess, Kristina Chen, Katherine G. Wiley, Henry Keenan, Tiarnan D. L. Agrón, Elvira Chew, Emily Y. Cukras, Catherine A. |
author_facet | Dave, Amisha D. Hess, Kristina Chen, Katherine G. Wiley, Henry Keenan, Tiarnan D. L. Agrón, Elvira Chew, Emily Y. Cukras, Catherine A. |
author_sort | Dave, Amisha D. |
collection | PubMed |
description | PURPOSE: To investigate potential associations between renal function and age-related macular degeneration (AMD) features as assessed with multimodal retinal imaging. METHODS: A subset of participants included in a dark adaptation study with varying AMD severities had estimated glomerular filtration rate (eGFR) values (mL/min/1.73 m(2)) obtained from renal function laboratory testing of serum creatinine and cystatin C. Multimodal imaging from visit dates associated with serum samples was graded by the Wisconsin Reading Center for AMD features. Associations of eGFR with AMD features and severity grades, age, smoker status and rod–intercept time were investigated. Simple univariate analyses, age-corrected multivariate analyses, and a feature-selecting least absolute shrinkage and selection operator regression were performed for eGFR as a continuous dependent variable. RESULTS: A total of 110 patients (mean age, 75.1 ± 9.4 years; mean eGFR, 70.7 ± 18.2 mL/min/1.73 m(2)) were included. In univariate analyses age (estimate, −1.16 units/year; 95% confidence interval [CI], −1.46 to −0.87; P < 0.0001), rod–intercept time (estimate, −0.54 units/minute; 95% CI, −0.81 to −0.27; P < 0.001) and subretinal drusenoid deposits (−11.12 units for subretinal drusenoid deposit presence in either eye; 95% CI, −20.23 to −2.01; P = 0.017) were associated with decreased renal function. However, in age-corrected multivariate models, age was the only significant variable associated with renal function, confirmed by least absolute shrinkage and selection operator regression. CONCLUSIONS: Accounting for age, renal function parameters did not show an association with AMD features. TRANSLATIONAL RELEVANCE: Bruch's membrane of the eye and the glomerular basement membrane of the kidney share physiologic similarities such that decreased renal function may demonstrate associations with AMD phenotypes. |
format | Online Article Text |
id | pubmed-9766786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-97667862022-12-21 Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes Dave, Amisha D. Hess, Kristina Chen, Katherine G. Wiley, Henry Keenan, Tiarnan D. L. Agrón, Elvira Chew, Emily Y. Cukras, Catherine A. Transl Vis Sci Technol Retina PURPOSE: To investigate potential associations between renal function and age-related macular degeneration (AMD) features as assessed with multimodal retinal imaging. METHODS: A subset of participants included in a dark adaptation study with varying AMD severities had estimated glomerular filtration rate (eGFR) values (mL/min/1.73 m(2)) obtained from renal function laboratory testing of serum creatinine and cystatin C. Multimodal imaging from visit dates associated with serum samples was graded by the Wisconsin Reading Center for AMD features. Associations of eGFR with AMD features and severity grades, age, smoker status and rod–intercept time were investigated. Simple univariate analyses, age-corrected multivariate analyses, and a feature-selecting least absolute shrinkage and selection operator regression were performed for eGFR as a continuous dependent variable. RESULTS: A total of 110 patients (mean age, 75.1 ± 9.4 years; mean eGFR, 70.7 ± 18.2 mL/min/1.73 m(2)) were included. In univariate analyses age (estimate, −1.16 units/year; 95% confidence interval [CI], −1.46 to −0.87; P < 0.0001), rod–intercept time (estimate, −0.54 units/minute; 95% CI, −0.81 to −0.27; P < 0.001) and subretinal drusenoid deposits (−11.12 units for subretinal drusenoid deposit presence in either eye; 95% CI, −20.23 to −2.01; P = 0.017) were associated with decreased renal function. However, in age-corrected multivariate models, age was the only significant variable associated with renal function, confirmed by least absolute shrinkage and selection operator regression. CONCLUSIONS: Accounting for age, renal function parameters did not show an association with AMD features. TRANSLATIONAL RELEVANCE: Bruch's membrane of the eye and the glomerular basement membrane of the kidney share physiologic similarities such that decreased renal function may demonstrate associations with AMD phenotypes. The Association for Research in Vision and Ophthalmology 2022-12-16 /pmc/articles/PMC9766786/ /pubmed/36525252 http://dx.doi.org/10.1167/tvst.11.12.11 Text en Copyright 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Retina Dave, Amisha D. Hess, Kristina Chen, Katherine G. Wiley, Henry Keenan, Tiarnan D. L. Agrón, Elvira Chew, Emily Y. Cukras, Catherine A. Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title | Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title_full | Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title_fullStr | Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title_full_unstemmed | Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title_short | Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes |
title_sort | investigations of renal function and age-related macular degeneration phenotypes |
topic | Retina |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766786/ https://www.ncbi.nlm.nih.gov/pubmed/36525252 http://dx.doi.org/10.1167/tvst.11.12.11 |
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