SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING

BACKGROUND: We explored whether the balance between innate and adaptive immune system links social health to cognitive brain aging in community-dwelling older adults. METHODS: Social health markers (social support, marital status, loneliness) were measured in the Rotterdam Study in 2002-2008. Balanc...

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Autores principales: van der Velpen, Isabelle, Yaqub, Amber, Vernooij, Meike, Perry, Marieke, Vernooij-Dassen, Myrra, Ghanbari, Mohsen, Ikram, Arfan, Melis, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766805/
http://dx.doi.org/10.1093/geroni/igac059.1707
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author van der Velpen, Isabelle
Yaqub, Amber
Vernooij, Meike
Perry, Marieke
Vernooij-Dassen, Myrra
Ghanbari, Mohsen
Ikram, Arfan
Melis, Rene
author_facet van der Velpen, Isabelle
Yaqub, Amber
Vernooij, Meike
Perry, Marieke
Vernooij-Dassen, Myrra
Ghanbari, Mohsen
Ikram, Arfan
Melis, Rene
author_sort van der Velpen, Isabelle
collection PubMed
description BACKGROUND: We explored whether the balance between innate and adaptive immune system links social health to cognitive brain aging in community-dwelling older adults. METHODS: Social health markers (social support, marital status, loneliness) were measured in the Rotterdam Study in 2002-2008. Balance of the immune system was assessed using white blood-cell-based indices (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII)) during the same visit. Cognitive function and total brain volume were measured at the 2009-2014 follow-up visit. RESULTS: In 8375 adults (mean age 65.7, 57% female), never married participants had higher NLR, PLR and SII compared to married peers, indicating imbalance towards innate immunity. Widowed/divorced males, but not females, had higher NLR, PLR and SII. Immune system balance did not mediate associations between social health and cognitive brain aging. Discussion: Social health is sex-differentially associated with immune system balance, but does not link to cognitive brain aging through mediation.
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spelling pubmed-97668052022-12-20 SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING van der Velpen, Isabelle Yaqub, Amber Vernooij, Meike Perry, Marieke Vernooij-Dassen, Myrra Ghanbari, Mohsen Ikram, Arfan Melis, Rene Innov Aging Abstracts BACKGROUND: We explored whether the balance between innate and adaptive immune system links social health to cognitive brain aging in community-dwelling older adults. METHODS: Social health markers (social support, marital status, loneliness) were measured in the Rotterdam Study in 2002-2008. Balance of the immune system was assessed using white blood-cell-based indices (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII)) during the same visit. Cognitive function and total brain volume were measured at the 2009-2014 follow-up visit. RESULTS: In 8375 adults (mean age 65.7, 57% female), never married participants had higher NLR, PLR and SII compared to married peers, indicating imbalance towards innate immunity. Widowed/divorced males, but not females, had higher NLR, PLR and SII. Immune system balance did not mediate associations between social health and cognitive brain aging. Discussion: Social health is sex-differentially associated with immune system balance, but does not link to cognitive brain aging through mediation. Oxford University Press 2022-12-20 /pmc/articles/PMC9766805/ http://dx.doi.org/10.1093/geroni/igac059.1707 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstracts
van der Velpen, Isabelle
Yaqub, Amber
Vernooij, Meike
Perry, Marieke
Vernooij-Dassen, Myrra
Ghanbari, Mohsen
Ikram, Arfan
Melis, Rene
SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title_full SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title_fullStr SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title_full_unstemmed SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title_short SOCIAL HEALTH AND IMMUNE SYSTEM IMBALANCE: SEX-SPECIFIC ASSOCIATIONS AND CAUSAL LINKS TO BRAIN AGING
title_sort social health and immune system imbalance: sex-specific associations and causal links to brain aging
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766805/
http://dx.doi.org/10.1093/geroni/igac059.1707
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