The role of chance in cancer causation

In the last years, the discussion about the role of chance in the causation of cancer has generated a large scientific and public debate. The concept that chance, or “bad luck”, as responsible for a majority of the variation of cancer incidence, may be misleading, possibly causing an underestimation...

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Autores principales: Angelini, Marco, Collatuzzo, Giulia, Teglia, Federica, Sassano, Michele, Siea, Andrei Cosmin, Boffetta, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 srl 2022
Materias:
Reviews, Commentaries, Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766839/
https://www.ncbi.nlm.nih.gov/pubmed/36475502
http://dx.doi.org/10.23749/mdl.v113i6.13867
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author Angelini, Marco
Collatuzzo, Giulia
Teglia, Federica
Sassano, Michele
Siea, Andrei Cosmin
Boffetta, Paolo
author_facet Angelini, Marco
Collatuzzo, Giulia
Teglia, Federica
Sassano, Michele
Siea, Andrei Cosmin
Boffetta, Paolo
author_sort Angelini, Marco
collection PubMed
description In the last years, the discussion about the role of chance in the causation of cancer has generated a large scientific and public debate. The concept that chance, or “bad luck”, as responsible for a majority of the variation of cancer incidence, may be misleading, possibly causing an underestimation of the role played by known risk factors. In this commentary we discuss how host and external factors interact with chance in cancer causation in different ways, and provide examples of situations where chance appears to play only a minor role on cancer onset.
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spelling pubmed-97668392022-12-28 The role of chance in cancer causation Angelini, Marco Collatuzzo, Giulia Teglia, Federica Sassano, Michele Siea, Andrei Cosmin Boffetta, Paolo Med Lav Reviews, Commentaries, Perspectives In the last years, the discussion about the role of chance in the causation of cancer has generated a large scientific and public debate. The concept that chance, or “bad luck”, as responsible for a majority of the variation of cancer incidence, may be misleading, possibly causing an underestimation of the role played by known risk factors. In this commentary we discuss how host and external factors interact with chance in cancer causation in different ways, and provide examples of situations where chance appears to play only a minor role on cancer onset. Mattioli 1885 srl 2022 2022-12-07 /pmc/articles/PMC9766839/ /pubmed/36475502 http://dx.doi.org/10.23749/mdl.v113i6.13867 Text en Copyright: © 2022 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Reviews, Commentaries, Perspectives
Angelini, Marco
Collatuzzo, Giulia
Teglia, Federica
Sassano, Michele
Siea, Andrei Cosmin
Boffetta, Paolo
The role of chance in cancer causation
title The role of chance in cancer causation
title_full The role of chance in cancer causation
title_fullStr The role of chance in cancer causation
title_full_unstemmed The role of chance in cancer causation
title_short The role of chance in cancer causation
title_sort role of chance in cancer causation
topic Reviews, Commentaries, Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766839/
https://www.ncbi.nlm.nih.gov/pubmed/36475502
http://dx.doi.org/10.23749/mdl.v113i6.13867
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