SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS

Mobility impairment is the most common disability among older adults, with an earlier presentation, higher prevalence, and greater severity in women compared to men. A decline in skeletal muscle metabolism contributes to the loss of mobility with age. However, it is unknown if sex-specific differenc...

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Autores principales: Kramer, Philip, Distefano, Giovanna, Ramos, Sofhia, Goodpaster, Bret, Coen, Paul, Marcinek, David, Cawthon, Peggy, Molina, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Late Breaking Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766933/
http://dx.doi.org/10.1093/geroni/igac059.2914
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author Kramer, Philip
Distefano, Giovanna
Ramos, Sofhia
Goodpaster, Bret
Coen, Paul
Marcinek, David
Cawthon, Peggy
Molina, Anthony
author_facet Kramer, Philip
Distefano, Giovanna
Ramos, Sofhia
Goodpaster, Bret
Coen, Paul
Marcinek, David
Cawthon, Peggy
Molina, Anthony
author_sort Kramer, Philip
collection PubMed
description Mobility impairment is the most common disability among older adults, with an earlier presentation, higher prevalence, and greater severity in women compared to men. A decline in skeletal muscle metabolism contributes to the loss of mobility with age. However, it is unknown if sex-specific differences in muscle energetics can explain the disparity in mobility impairment among men and women. In the Study of Muscle, Mobility, and Aging (SOMMA), muscle energetics was characterized using in vivo Phosphorus Magnetic Resonance Spectroscopy and High-Resolution Respirometry of permeabilized fiber bundles from muscle biopsies. In this analysis of 773 participants aged 70–94 years, 519 were women, of which 16% were deemed lower extremity mobility impaired based on a Short Physical Performance Battery (SPPB) score
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spelling pubmed-97669332022-12-21 SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS Kramer, Philip Distefano, Giovanna Ramos, Sofhia Goodpaster, Bret Coen, Paul Marcinek, David Cawthon, Peggy Molina, Anthony Innov Aging Late Breaking Abstracts Mobility impairment is the most common disability among older adults, with an earlier presentation, higher prevalence, and greater severity in women compared to men. A decline in skeletal muscle metabolism contributes to the loss of mobility with age. However, it is unknown if sex-specific differences in muscle energetics can explain the disparity in mobility impairment among men and women. In the Study of Muscle, Mobility, and Aging (SOMMA), muscle energetics was characterized using in vivo Phosphorus Magnetic Resonance Spectroscopy and High-Resolution Respirometry of permeabilized fiber bundles from muscle biopsies. In this analysis of 773 participants aged 70–94 years, 519 were women, of which 16% were deemed lower extremity mobility impaired based on a Short Physical Performance Battery (SPPB) score Oxford University Press 2022-12-20 /pmc/articles/PMC9766933/ http://dx.doi.org/10.1093/geroni/igac059.2914 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Late Breaking Abstracts
Kramer, Philip
Distefano, Giovanna
Ramos, Sofhia
Goodpaster, Bret
Coen, Paul
Marcinek, David
Cawthon, Peggy
Molina, Anthony
SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title_full SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title_fullStr SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title_full_unstemmed SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title_short SEX DIFFERENCES IN SKELETAL MUSCLE ENERGETICS AMONG OLDER ADULTS
title_sort sex differences in skeletal muscle energetics among older adults
topic Late Breaking Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9766933/
http://dx.doi.org/10.1093/geroni/igac059.2914
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